Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Man;Xie, Yafeng;Zheng, Kang;Luo, Haodang;Tan, Manyi;...

通讯作者：

Wu, Yimou

作者机构：

[Wu, Yimou; Zhao, Feijun; Xie, Yafeng; Xu, Man; Zeng, Tiebing] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hengyang, Peoples R China.

[Wu, Yimou; Zhao, Feijun; Xie, Yafeng; Xu, Man; Zeng, Tiebing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

[Xie, Yafeng] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Dept Clin Lab, Hengyang, Peoples R China.

[Zheng, Kang] Hengyang Cent Hosp, Dept Clin Lab, Hengyang, Peoples R China.

[Luo, Haodang] Univ South China, Hengyang Med Sch, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hengyang, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

语种：

英文

关键词：

Treponema pallidum;Tp0136;Tp0663;Vaccine candidate;dissemination

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2021

卷：

页码：

759474

DOI：

10.3389/fimmu.2021.759474

基金类别：

This work was supported by the National Natural Science Foundation of China (grant numbers 82002182, 81702046, and 81471576), Natural Science Foundation of Hunan Province (grant numbers 2021JJ40479 and 2019JJ50535), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (grant number 2015-351), and Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant number 2014-5).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a major public health problem worldwide. Recent increases in the number of syphilis cases, in addition to the lack of an efficient vaccine against T. pallidum for humans, highlights an urgent need for the design and development of an efficacious syphilis vaccine. Here, we assess the vaccine potential of the adhesion protein Tp0136 and the outer membrane protein Tp0663. Rabbits were subcutaneously immunized with recombinant proteins Tp0136, Tp0663, or control PBS. Immunization with Tp0136 or Tp0663 genera...

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Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum

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