MiR-184 targeting FOXO1 regulates host-cell oxidative stress induced by Chlamydia psittaci via the Wnt/β-catenin signaling pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Lili;Huang, Qiaoling;Luo, Yuchen;Zhou, You;Tong, Ting;...

通讯作者：

Chen, LL;Li, ZY

作者机构：

[Bai, Qinqin; Chen, Lili; Zhou, You; Huang, Qiaoling; Tong, Ting; Luo, Yuchen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang, Peoples R China.

[Chen, Yuyu] Cent South Univ, Xiangya Sch Med, Hunan Canc Hosp, Changsha, Peoples R China.

[Chen, Yuyu] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Peoples R China.

[Li, Zhongyu; Lu, Chunxue; Li, ZY] Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang, Peoples R China.

通讯机构：

[Li, ZY ; Chen, LL ] U

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang, Peoples R China.

Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang, Peoples R China.

语种：

英文

关键词：

Chlamydia psittaci;FOXO1;MiR-184;Wnt/β-catenin signaling pathway;oxidative stress

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2023

卷：

期：

页码：

e0033723

DOI：

10.1128/iai.00337-23

基金类别：

Scientific Research Fund of Hunan Provincial Education Department

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Chlamydia psittaci is a human pathogen that causes atypical pneumonia after zoonotic transmission. We confirmedthat C. psittaci infection induces oxidative stress in human bronchial epithelial (HBEs) cells and explored how this is regulated through miR-184 and the Wnt/β-catenin signaling pathway. miR-184 mimic, miR-184 inhibitor, FOXO1 siRNA, or negative control sequence was transfected into HBE cells cultured in serum-free medium using Lipofectamine 2000. Then, prior to the cells were infected with C. psittaci 6BC, and the cells were treated ...

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MiR-184 targeting FOXO1 regulates host-cell oxidative stress induced by Chlamydia psittaci via the Wnt/β-catenin signaling pathway

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