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Current Advances of Mitochondrial Dysfunction and Cardiovascular Disease and Promising Therapeutic Strategies

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成果类型:
期刊论文
作者:
Xia, Dexiang;Liu, Yue;Wu, Peng;Wei, Dangheng
通讯作者:
Wei, DH
作者机构:
[Liu, Yue; Xia, Dexiang; Wei, Dangheng] Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang, Peoples R China.
[Wu, Peng] Hengyang Maternal & Child Hlth Hosp, Hengyang, Peoples R China.
[Wei, Dangheng] Univ South China, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Wei, DH ] U
Univ South China, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
期刊:
AMERICAN JOURNAL OF PATHOLOGY
ISSN:
0002-9440
年:
2023
卷:
193
期:
10
页码:
1485-1500
基金类别:
Supported by the National Natural Science Foundation of China [grants 31870937 (D.W.) and 82000421 (P.W. )], the National College Students Innovation and Entrepreneurship Training Program (grant 202210555075 ) (D.X.), and the Natural Science Foundation of Hunan Province (grant S2022JJQNJJ0152 ) (D.W.) and the Scientific Research Fund Project of Hunan Provincial Health Commission (grant 20200011–1003 ) (D.W.).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Mitochondria are cellular power stations and essential organelles for maintaining cellular homeostasis. Dysfunctional mitochondria have emerged as a key factor in the occurrence and development of cardiovascular disease. This review focuses on advances in the relationship between mitochondrial dysfunction and cardiovascular diseases such as atherosclerosis, heart failure, myocardial ischemia reperfusion injury, and pulmonary arterial hypertension. The clinical value and challenges of mitochondria-targeted strategies, including mitochondria-targ...

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