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Myocardial ischemic preconditioning upregulated protein 1(Mipu1):Zinc finger protein 667 – A multifunctional KRAB/C2H2 zinc finger protein

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成果类型:
期刊论文
作者:
Han, D.;Zhang, C.;Fan, W. J.;Pan, W. J.;Feng, D. M.;...
通讯作者:
Qu, S. L.
作者机构:
[Zhang, C.; Pan, W. J.; Fan, W. J.; Han, D.; Jiang, Z. S.; Qu, S. L.; Feng, D. M.] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Postdoctoral Mobile Stn Basic Med, Hengyang City, Hunan, Peoples R China.
[Fan, W. J.] Univ South China, Affiliated Hosp 2, Hengyang City, Hunan, Peoples R China.
通讯机构:
[Qu, S. L.] U
Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Postdoctoral Mobile Stn Basic Med, Hengyang City, Hunan, Peoples R China.
语种:
英文
关键词:
Mipu1;Zinc finger structure;Nuclear factor;Transcription and repression
期刊:
Brazilian Journal of Medical and Biological Research
ISSN:
0100-879X
年:
2015
卷:
48
期:
1
页码:
1-5
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100212, 81170277, 81100106]; PhD Programs Foundation of the Ministry of Education of the People's Republic of China [20114324120004, 20124324110003]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012 M511383]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [11C1094, 11C1095]; Science and Technology Project of Hunan Province [2014FJ3014]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; Construct Program of the Key Discipline in Human Hunan Province [2011-76]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. Mipu1 cDNA contains a 1824-base pair open reading frame and encodes a 608 amino acid protein with an N-terminal Kru¨ ppel-associated box (KRAB) domain and classical zinc finger C2H2 motifs in the C-terminus. Mipu1 protein is located in the cell nucleus. Recent studies found that Mipu1 has a protective effect on the ischemia-reperfusion injury of heart, brain, and other...

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