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Research on a kind of biocompatible molecularly imprinted materials with silybin controlled release based on pH/temperature dual responses

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成果类型:
期刊论文
作者:
Tan, Ni*;Ji, Kang;He, Dianxiong;Liao, Sen;He, Leqing;...
通讯作者:
Tan, Ni
作者机构:
[Han, Jingwen; Ji, Kang; Liao, Sen; Tan, Ni; Liu, Yaqing; He, Dianxiong; Chen, Can; He, Leqing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Tan, Ni] U
Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Silybin;Biocompatible;Magnetic molecularly imprinted polymer;Drug release;pH/temperature dual responses
期刊:
Reactive and Functional Polymers
ISSN:
1381-5148
年:
2020
卷:
147
页码:
104449
基金类别:
Scientific Research Project of Education Department of Hunan [17C1359]; Research Learning and Innovative Experimental Program of Hunan/South China University [S201910555016, X2019070, X2019071]
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
摘要:
Silybin, a hepatoprotective active natural ingredient, was used as the template, methyl acrylic acid (MAA) as the functional monomer, n-isopropyl acrylamide (NIPAm) as the thermal response monomer, magnetic core Fe3O4@CS@APTES@BiBB coated by biocompatible chitosan as the carrier, and a kind of silybin molecularly imprinted materials (MMIPs) based on pH/temperature dual responses were prepared by electron transfer activation regenerative catalyst atom transfer radical polymerization (ARGET ATRP). The synthesized material was characterized by FT-IR, TGA, SEM, XRD, VSM, and XPS, and the loading b...

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