NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Wenjuan;Li, Xiaoling;Wang, Wei;Li, Xiayu;Tan, Yixin;...

通讯作者：

Xiang, Bo

作者机构：

[Li, Wenjuan; Zhang, Zuping; Li, Xiaoling; Wang, Wei; Ma, Jian; Xiong, Wei; Wu, Minghua; Liao, Qianjin; Xiang, Bo; Li, Guiyuan; Yi, Mei] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.

[Li, Xiayu] Cent S Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410013, Hunan, Peoples R China.

[Tan, Yixin] Cent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410008, Hunan, Peoples R China.

[Yi, Mei] Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha 410008, Hunan, Peoples R China.

[McCarthy, James B.; Yang, Jianbo] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.

通讯机构：

[Xiang, Bo] C

Cent S Univ, Xiangya Sch Med, Canc Res Inst, Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

期刊：

CARCINOGENESIS

ISSN：

0143-3334

年：

2011

卷：

期：

页码：

1305-1314

DOI：

10.1093/carcin/bgr174

基金类别：

National High-tech R&D Program (863 Program) of China (No. 2007AA02Z170); the National Natural Science Foundation of China (Nos. 81000883, 30971147, 30871282, 30871365, 81072270); the National ‘111’ Project of China (No.111-2-12); Natural Science Foundation of Hunan Province, People’s Republic of China (10JJ7003), the Free Exploration Program of Central South University of China (Nos. 201012200017,2011QNZT138) and the Graduate Innovation Foundation of Central South University of China (No. 2010ssxt048).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Promoter hypermethylation-mediated silencing of tumor suppressor genes (TSGs) is a hallmark of oncogenesis. Oxidored-nitro domain-containing protein 1 (NOR1) is a candidate TSG that is downregulated in nasopharyngeal carcinoma (NPC). In the present study, we identified a functional NOR1 promoter that is regulated by heat shock factor 1 and nuclear respiratory factor 1. The promoter is located within a CpG island. Hypermethylation of this CpG island was found in NPC tissue samples and cancer cell lines, whereas no aberrant promoter methylation w...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问