Impaired lipophagy in endothelial cells with prolonged exposure to oxidized low-density lipoprotein

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成果类型：

期刊论文

作者：

Zhang, Cai-Ping;Ding, Xin-Xin;Tian, Tian;Li, Bo-Jie;Wang, Chu-Yao;...

通讯作者：

Zhang, Min;Long, Shi-Yin

作者机构：

[Shao, Jin-Qi; Ding, Xin-Xin; Wang, Chu-Yao; Tian, Ying; Long, Shi-Yin; Zhang, Cai-Ping; Yuan, Yu-Lin; Zhang, M; Long, SY; Li, Bo-Jie; Jiang, Su-Su; Zhang, Min] Univ South China, Med Coll, Dept Biochem & Mol Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Ding, Xin-Xin] Second People Hosp Dezhou, Dept Pathol, Dezhou 253000, Shandong, Peoples R China.

[Tian, Tian] First Hosp Changsha, Dept Clin Lab, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Zhang, M; Long, SY] U

Univ South China, Med Coll, Dept Biochem & Mol Biol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

oxidized low density lipoprotein;low density lipoprotein;oxidized low density lipoprotein;apoptosis;Article;autophagy (cellular);controlled study;coronary artery atherosclerosis;electron microscopy;endothelium cell;human;human cell;human cell culture;HUVEC cell line;lipid storage;lipophagocytosis;long term exposure;lysosome;MTT assay;oxidative stress;transmission electron microscopy;Western blotting;autophagy;cell line;cell survival;cytology;drug effect;lipid metabolism;metabolism;umbilical vein endothelial cell;Autophagy;Cell Line;Cell Survival;Human Umbilical Vein Endothelial Cells;Humans;Lipid Metabolism;Lipoproteins, LDL;Microscopy, Electron;Oxidative Stress

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2020

卷：

期：

页码：

2665-2672

DOI：

10.3892/mmr.2020.11345

基金类别：

The present study was supported by the National Nature Science Fund of China (grant nos. 81600291 and 31871169), the Nature Science Fund of Hunan province (grant nos. 2018JJ2346 and 2018JJ2348) and the Hunan Provincial Innovation Foundation for Postgraduate (grant no. CX2018B62). The present study was supported by the national nature Science Fund of china (grant nos. 81600291 and 31871169), the nature Science Fund of Hunan province (grant nos. 2018JJ2346 and 2018JJ2348) and the Hunan Provincial innovation Foundation for Postgraduate (grant no. cX2018B62).

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Oxidative stress induces the formation of oxidized low-density lipoprotein (ox-LDL ), which accelerates the development of atherosclerosis and the rupture of atherosclerotic plaques by promoting lipid accumulation and inhibiting autophagy in vascular cells. Lipophagy is known to be involved in maintaining the balance of neutral lipid metabolism; however, the phenomenon of lipophagy deficiency in ox-LDL- treated endothelial cells (EC s) remains to be elucidated. It has been demonstrated that lipid accumulation caused by ox-LDL inhibits autophagy...

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Impaired lipophagy in endothelial cells with prolonged exposure to oxidized low-density lipoprotein

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