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Histone H3Y99sulf regulates hepatocellular carcinoma responding to hypoxia

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成果类型:
期刊论文
作者:
Yin, Sibi;Yu, Weixing;Zhou, Runxin;Zeng, Xiao;Jiang, Li;...
通讯作者:
Wang, Yugang
作者机构:
[Zeng, Xiao; Zhou, Runxin; Wang, Yu; Tong, Fuqiang; Guo, Dingyuan; Yin, Sibi; Wang, Yugang] Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China
[Yu, Weixing] Department of Biochemistry and Molecular Biology, College of Basic Medicine, Jining Medical University, Jining, 272067, China
[Jiang, Li] Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China, 430060
[Jiang, Li] Department of Neurology, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, China
[He, Leya] Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
通讯机构:
[Yugang Wang] D
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China<&wdkj&>Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan, Hubei, China
语种:
英文
关键词:
histone sulfation;regulation of gene transcription;hypoxia;glycolysis;PDK1
期刊:
Journal of Biological Chemistry
ISSN:
0021-9258
年:
2024
卷:
300
期:
3
页码:
105721
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Histone H3 tyrosine-99 sulfation (H3Y99sulf) is a recently identified histone mark that can cross-talk with H4R3me2a to regulate gene transcription, but its role in cancer biology is less studied. Here, we report that H3Y99sulf is a cancer-associated histone mark that can mediate hepatocellular carcinoma (HCC) cells responding to hypoxia. Hypoxia-stimulated SNAIL pathway elevates the expression of PAPSS2, which serves as a source of adenosine 3′-phosphate 5′-phos-phosulfate for histone sulfation and results in upregulation of H3Y99sulf. The t...

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