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Histone H3Y99sulf regulates hepatocellular carcinoma responding to hypoxia

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成果类型:
期刊论文
作者:
Yin, Sibi;Yu, Weixing;Zhou, Runxin;Zeng, Xiao;Jiang, Li;...
通讯作者:
Wang, YG
作者机构:
[Zeng, Xiao; Zhou, Runxin; Wang, Yu; Tong, Fuqiang; Guo, Dingyuan; Wang, Yugang; Yin, Sibi] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Biochem & Mol Biol, Wuhan, Hubei, Peoples R China.
[Yu, Weixing] Jining Med Univ, Coll Basic Med, Dept Biochem & Mol Biol, Jining, Peoples R China.
[Jiang, Li] Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan, Hubei, Peoples R China.
[Jiang, Li] Univ South China, Nanhua Hosp, Dept Neurol, Hengyang, Peoples R China.
[He, Leya] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastrointestinal Surg, Wuhan, Hubei, Peoples R China.
通讯机构:
[Wang, YG ] H
Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Biochem & Mol Biol, Wuhan, Hubei, Peoples R China.
Huazhong Univ Sci & Technol, Cell Architecture Res Ctr, Wuhan, Hubei, Peoples R China.
语种:
英文
关键词:
Amino acids;Diseases;Cancer biology;Gene transcriptions;Glycolysis;Hepatocellular carcinoma;Histone H3;Histone sulphation;Hypoxia;PDK1;Regulation of gene transcription;Sulphation;Transcription;H3Y99sulf;histone;hypoxia inducible factor 1alpha;phosphoinositide dependent protein kinase 1;transcription factor;transcription factor Snail;transcriptome;unclassified drug;AMPK signaling;Article;chromatin immunoprecipitation;controlled study;epigenetics;genetic transcription;glycolysis;hepatocellular carcinoma cell line;human;human cell;hypoxia;immunoblotting;immunoprecipitation;liver cell carcinoma;mouse;nonhuman;physiological stress;promoter region;protein expression;real time polymerase chain reaction;transcription elongation;tumor growth;tumor metabolism
期刊:
Journal of Biological Chemistry
ISSN:
0021-9258
年:
2024
卷:
300
期:
3
页码:
105721
基金类别:
This work was supported by the National Natural Science Foundation of China ( 32270642 , 91957110 , and 31970577 ).
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Histone H3 tyrosine-99 sulfation (H3Y99sulf) is a recently identified histone mark that can cross-talk with H4R3me2a to regulate gene transcription, but its role in cancer biology is less studied. Here, we report that H3Y99sulf is a cancer-associated histone mark that can mediate hepatocellular carcinoma (HCC) cells responding to hypoxia. Hypoxia-stimulated SNAIL pathway elevates the expression of PAPSS2, which serves as a source of adenosine 3′-phosphate 5′-phos-phosulfate for histone sulfation and results in upregulation of H3Y99sulf. The t...

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