Facile construction of stabilized, pH-sensitive micelles based on cyclic statistical copolymers of poly(oligo(ethylene glycol)methyl ether methacrylate-st-N,N-dimethylaminoethyl methacrylate) for in vitro anticancer drug delivery

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成果类型：

期刊论文

作者：

Zhang, Miao;Liu, Ying;Peng, Jinlei;Liu, Yuping;Liu, Fangjun;...

通讯作者：

Wei, Hua

作者机构：

[Zhang, Miao; Liu, Yuping; Peng, Jinlei; Wei, Hua; Ma, Wei; Ma, Liwei; Liu, Fangjun] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

[Zhang, Miao; Liu, Yuping; Peng, Jinlei; Wei, Hua; Ma, Wei; Ma, Liwei; Liu, Fangjun] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Liu, Ying; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Liu, Ying; Yu, Cui-Yun] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Wei, Hua] L

[Wei, Hua] U

Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Polymer Chemistry

ISSN：

1759-9954

年：

2020

卷：

期：

页码：

6139-6148

DOI：

10.1039/d0py01076f

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473072, 21504035]; Thousand Young Talent Program; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Cyclic polymers have outperformed their linear analogues for controlled release applications in terms of greater stability and better therapeutic efficiency due to the endless chain topology. However, to our knowledge, there have been thus far only a few examples of the fabrication of pH-sensitive cyclic polymers for drug delivery applications. To further improve the colloidal stability of the previously synthesized cyclic poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) for drug delivery applications via a facile yet efficient approach, it will be useful and straightforward to incorporate ...

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Facile construction of stabilized, pH-sensitive micelles based on cyclic statistical copolymers of poly(oligo(ethylene glycol)methyl ether methacrylate-st-N,N-dimethylaminoethyl methacrylate) for in vitro anticancer drug delivery

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