Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Qiuxia;Chen, Hongfei;Ren, Yuyan;Wang, Zhe;Zeng, Peiyu;...

通讯作者：

Zheng, Xing

作者机构：

[Wang, Zhe; Li, Xuan; Chen, Hongfei; Ren, Yuyan; Zeng, Peiyu; Wang, Juan; Huang, Qiuxia; Zheng, Xing] Univ South China, Dept Pharm Pharmacol, Hengyang, Peoples R China.

[Wang, Zhe; Li, Xuan; Chen, Hongfei; Ren, Yuyan; Zeng, Peiyu; Wang, Juan; Huang, Qiuxia; Zheng, Xing] Hunan Prov Cooperat Innovat Ctr Mol Target New D, Hengyang, Peoples R China.

[Zeng, Peiyu] Univ South China, Res Interest Grp Pharm, Hengyang, Peoples R China.

[Zheng, Xing] Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Zheng, Xing] U

[Zheng, Xing] H

Univ South China, Dept Pharm Pharmacol, Hengyang, Peoples R China.

Hunan Prov Cooperat Innovat Ctr Mol Target New D, Hengyang, Peoples R China.

Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

HCC;mechanisms;structural modification;structure activity relationship

期刊：

Pharmaceutical Biology

ISSN：

1388-0209

年：

2016

卷：

期：

页码：

3189-3196

DOI：

10.1080/13880209.2016.1214742

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273537]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [12K095]; key disciplines of Hunan Province; University of South China

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Context: Hepatocellular carcinoma (HCC) is a common cancer around the world, with high mortality rate. Currently, there is no effective drug for the therapy of HCC. Ursolic acid (UA) is a natural product which exists in various medicinal herbs and fruits, exhibiting multiple biological effects such as its outstanding anticancer and hepatoprotective activity, which has drawn many pharmacists' attention. Objective: This paper summarizes the current status of the hepatoprotective activity of UA analogues and explains the related mechanism, providing a clear direction for the development of novel ...

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