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Glycogen-binding protein STBD1: Molecule and role in pathophysiology

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成果类型:
期刊论文
作者:
Tang, Qiannan;Liu, Meiqing;Zhao, Hong;Chen, Linxi
通讯作者:
Chen, LX;Zhao, H
作者机构:
[Tang, Qiannan; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang, Peoples R China.
[Liu, Meiqing] Kunming Med Univ, Yanan Hosp, Key Lab Cardiovasc Dis Yunnan Prov, Key Lab Tumor Immunol Prevent & Treatment Yunnan P, Kunming, Peoples R China.
[Zhao, Hong] Univ South China, Nursing Coll, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.
通讯机构:
[Zhao, H ; Chen, LX ] U
Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang, Peoples R China.
Univ South China, Nursing Coll, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
glycogen;carcinogenesis;cellular distribution;diabetic cardiomyopathy;energy metabolism;gene deletion;gene mutation;glycogen storage disease type 2;heart muscle injury;pathophysiology;physiological process;protein function;Review;tissue distribution
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN:
0021-9541
年:
2023
卷:
238
期:
9
页码:
2010-2025
基金类别:
The study was supported by Grants from the National Science Foundation of China (81903615), Hunan Province Natural Science Foundation of China(2021JJ30606), Health Science and Technology Project of Kunming Municipal Health Commission (2022‐13‐01‐018), The Project of Science and Technology Department of Yunnan Province (202301AY070001‐155), and Kunming Health Science and Technology “Thousands” Talents Project (2021‐SW(reserve)‐10).
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Starch-binding domain-containing protein 1 (STBD1) is a glycogen-binding protein discovered in skeletal muscle gene differential expression that is pivotal to cellular energy metabolism. Recent studies have indicated that STBD1 is involved in many physiological processes, such as glycophagy, glycogen accumulation, and lipid droplet formation. Moreover, dysregulation of STBD1 causes multiple diseases, including cardiovascular disease, metabolic disease, and even cancer. Deletions and/or mutations in STBD1 promote tumorigenesis. Therefore, STBD1 ...

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