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The circadian clock regulates innate immunity and cardiovascular diseases

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成果类型:
期刊论文
作者:
Qiu, Dan;Li, Lixia;Yu, Xiaoqing;Xiao, Zhenhua;Chen, Keqian;...
通讯作者:
Wang, Zongbao;Wang, SZ
作者机构:
[Qiu, Dan; Xiao, Zhenhua; Wang, Zongbao; Yu, Xiaoqing; Li, Lixia; Wang, Shuzhi] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.
[Qiu, Dan; Xiao, Zhenhua; Wang, Zongbao; Yu, Xiaoqing; Li, Lixia; Wang, Shuzhi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New, Hengyang 421001, Peoples R China.
[Chen, Keqian] Hunan Univ, Xiangtan Cent Hosp, Affiliated Hosp, Dept Clin Pharm, Xiangtan 411100, Peoples R China.
通讯机构:
[Wang, SZ ; Wang, ZB] U
Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;Chronotherapy;Circadian clock;Inflammation;Innate immunity;Myocardial infarction
期刊:
European Journal of Pharmacology
ISSN:
0014-2999
年:
2025
卷:
1005
页码:
178050
基金类别:
CRediT authorship contribution statement Dan Qiu: Writing – review & editing, Data curation, Conceptualization. Lixia Li: Writing – review & editing. Xiaoqing Yu: Writing – review & editing, Visualization, Data curation. Zhenhua Xiao: Writing – review & editing, Supervision. Keqian Chen: Writing – review & editing, Supervision. Zongbao Wang: Supervision, acquisition. Shuzhi Wang: Supervision, acquisition, Conceptualization. This work was supported by the Natural Sciences Foundation of Hunan Province ( 2025JJ50664 ), the Scientific Research Project of Hunan Provincial Department of Education ( 23A0338 ), the Project of Hunan Provincial Health Committee ( D202302048902 ), and the College Student Innovation and Entrepreneurship Training Program of Hunan Province ( S202310555321 ), University of South China, China.
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Circadian rhythms are 24-h oscillating variations in physiology and behavior generated by the circadian clock, enabling an individual's circadian cycle to synchronize with the external light-dark cycle. The circadian clock precisely regulates multiple aspects of the innate immune system, including immune cells and diverse immune parameters. The oscillations of innate immune cells and their effector molecules typically determine the extent of the inflammatory responses. During the onset of cardiovascular diseases, many innate immune cells accumulate at the lesion sites. Their continuously augme...

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