The Magic and Mystery of TRIM65 in Diseases

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Qinyi;Li, Yuan;Zhou, Zhixiang;Zhou, Yiren;Liu, Yizhou;...

通讯作者：

Ma, XF

作者机构：

[Zhou, Yiren; Ma, Xiaofeng; Liu, Yizhou; Zhou, Qinyi; Ma, XF] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Qinyi; Zhou, Zhixiang] Univ South China, Hunan Int Sci & Technol Cooperat Base Arterioscler, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Li, Yuan] Univ South China, Affiliated Nanhua Hosp, Hlth Sch Nucl Ind, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Wang] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastrointestinal Surg, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Ma, XF ] U

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

E3 ubiquitin ligase;TRIM65;atherosclerosis;tumour;ubiquitin-proteasome system.;ubiquitination

期刊：

CURRENT MEDICINAL CHEMISTRY

ISSN：

0929-8673

年：

2024

DOI：

10.2174/0109298673304966240614091547

基金类别：

Key Guidance Program of the Health Commission of Hunan Province [20201905]; Clinical Medical Research Center of Hunan [2020SK4007]; Hunan Provincial Health Commission General Guidance project [D202303016868]; Major Scientific Research Project of Health High-Level Talents in Hunan Province [R2023068]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Tripartite-motif protein family member 65 (TRIM65) belongs to the tripartite motif (TRIM) protein family. Its typical structure consists of the RING, B-Box motif, and coiled-coil domains, which are highly conserved at the N-terminus and the variable SPRY domain at the C-terminus. TRIM65 is an E3 ubiquitin ligase that participates in physiological and pathological processes through the ubiquitination pathway, including intracellular signal transduction, protein degradation, cell proliferation, apoptosis, carcinogenesis, autophagy, and phenotypic transformation. Evidence shows that TRIM65 plays ...

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