通讯机构：
[Zeng, Gu-Qing] U;Univ South China, Sch Nursing, 28 Changsheng Rd West, Hengyang 421001, Hunan, Peoples R China.
关键词：
Selenium-binding protein 1;Lung squamous cell carcinoma;Prognosis
摘要：
We found that selenium-binding protein 1 (SBP1) was progressively decreased in the human bronchial epithelial carcinogenic processes. Knockdown of SBP1 in immortalized human bronchial epithelial cell line 16HBE cells significantly increased the efficiency of B[a]P-induced cell transformation. However, the relationship between SBP1 expression and clinicopathological factors of patients has not been defined completely. The specific role of SBP1 in prognosis of lung squamous cell carcinoma (LSCC) is still unknown. Tissue samples from 82 patients treated by pulmonary lobectomy for LSCC were used. Immunohistochemistry and western blotting were used to detect the expressions of SBP1 protein. The relationships between the expression level of SBP1 and the clinicopathological features of patients were analyzed. Cox proportional hazard regression analysis and Kaplan–Meier method were used to perform survival analysis. Expressions of SBP1 proteins were significantly lower in LSCC tissues than that in the corresponding normal bronchial epithelium (NBE) tissues (P = 0.000). In LSCC, The expression levels of SBP1 had not correlated with patients’ age, gender, smoking state, primary tumor stages (T), TNM clinical stages, and distant metastasis (M) (P > 0.05). However, downregulation of SBP1 was significantly associated with higher lymph node metastasis and lower overall survival rate (P < 0.05). Cox regression analysis indicated low expressions of SBP1 can be an independent prognostic factor for poor overall survival in LSCC patients (P = 0.002). Downregulation of SBP1 may play a key role in the tumorigenic process of LSCC. SBP1 may be a novel potential prognostic factor of LSCC.
作者机构：
[Duan, Gong-xiang; Su, Yin-hua; Jia, Hong-li] School of Nursing, University of South China, Hengyang, Hunan Province, People's Republic of China;[Wang, Ke] Hunan Cancer Hospital, Changsha, Hunan Province, People's Republic of China;[Tang, Shuang-yang] Medical School, University of South China, Hengyang, Hunan Province, People's Republic of China;[Chen, Xue-mei; Xie, Hong-hui] Community of Qingshan, Hengyang, Hunan Province, People's Republic of China
通讯机构：
[Ke Wang] H;Hunan Cancer Hospital, Changsha, Hunan Province, People's Republic of China
关键词：
Tai Chi;Telomerase activity;Gerotranscendence
摘要：
Introduction: Telomeres are DNA protein structures at the end of chromosomes and are linked to the physical aging process. The improvement of quality of life is closely associated with aerobic exercise, and the dynamic effects of exercise on physiology and psychology are evident with aging. Tai Chi is popularly practiced in China. However, findings on the effects of Tai Chi on telomerase activity (TA) in peripheral blood mononuclear cells, and gerotranscendence (GT), as well as the association of TA and GT with Tai Chi, have been inconsistent. Purpose: This study aims to assess TA in peripheral blood mononuclear cells, GT, and the associations between them. The associations among these variables are determined during six months of Tai Chi intervention among Chinese middle aged and elderly adults. Methods: TA assessment was obtained by TE-ELISA (human telomerase-enzyme linked immunosorbent assay), and GT was measured at the baseline level after six months of Tai Chi intervention. Results: TA increased significantly in the Tai Chi group from 23.75 +/- 3.78 u/mmol (preintervention) to 26.31 +/- 2.93 u/mmol (after 6 months) (p < 0.05). Compared with the TA in the control group, the TA in the intervention group was statistically significant after six months (p < 0.05). Compared with the GT in the control group, the GT in the intervention group improved significantly after six months (p < 0.05). TA and GT had a positive correlation (r = 0.325, p < 0.01). Conclusion: Our data illustrated that Tai Chi had a protective effect on TA and might improve the GT in Chinese middle aged and elderly adults. The TA increased with the increasing GT in Chinese middle aged and elderly adults. Copyright (C) 2016, Chinese Nursing Association. Production and hosting by Elsevier B.V.
