期刊:
Journal of Clinical Endocrinology & Metabolism,2023年 ISSN:0021-972X
通讯作者:
Zheng, MH;Valenti, L
作者机构:
[Liu, Wen-Yue] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou 325000, Peoples R China.;[Liu, Wen-Yue] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou Key Lab Diabet Res, Wenzhou 325000, Peoples R China.;[Zhang, Ni; Lian, Li-You; Ye, Chen-Hui; Zheng, Ming-Hua; Chen, Wen-Ying] Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, Wenzhou 325000, Peoples R China.;[Zhang, Ni; Lian, Li-You; Ye, Chen-Hui; Zheng, Ming-Hua; Chen, Wen-Ying] Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China.;[Zhang, Ni; Lian, Li-You; Ye, Chen-Hui; Zheng, Ming-Hua; Chen, Wen-Ying] Key Lab Diag & Treatment Dev Chron Liver Dis, Wenzhou, Zhejiang, Peoples R China.
通讯机构:
[Zheng, MH ] W;[Valenti, L ] U;Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.;Univ Milan, Dept Pathophysiol & Transplantat, Via Festa Perdono 7, I-20121 Milan, Italy.
关键词:
Iron overload;Metabolic dysfunction-associated fatty liver disease;Metabolic hyperferritinemia;Metabolic syndrome
摘要:
BACKGROUND: There is limited data on the clinical significance of metabolic hyperferritinemia (MHF) based on the most recent consensus. We aimed to validate the clinical outcomes of MHF in general population and biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD) patients. METHODS: NHANES database and PERSONS cohort were included. MHF was defined as elevated serum ferritin with metabolic dysfunction (MD) and stratified into different grades according to ferritin (grade 1: 200 [females]/300 [males] - 550 ng/ml; grade 2: 550 - 1000 ng/ml; grade 3: > 1000 ng/ml). The clinical outcomes, including all-cause death, comorbidities and liver histology were compared between non-MHF and MHF in adjusted models. RESULTS: In NHANES, compared with non-MHF with MD, MHF was related to higher risks of advanced fibrosis (FIB-4, P = 0.036), elevated albumin-creatinine ratio (UACR, P = 0.001) and sarcopenia (P = 0.013). Although the association between all grades of MHF and mortality was insignificant (P = 0.122), grades 2/3 was associated with increased mortality (P = 0.029). While comparing with non-MHF without MD, the harmful effects of MHF were more significant in mortality (P < 0.001), elevated UACR (P < 0.001), cardiovascular disease (P = 0.028), and sarcopenia (P < 0.001). In PERSONS cohort, MHF was associated with more advanced grades of steatosis (P < 0.001), lobular inflammation (P < 0.001), advanced fibrosis (P = 0.017), and more severe hepatocellular iron deposition (P < 0.001). CONCLUSIONS: Both in general population and at-risk individuals with MAFLD, MHF was related with poorer clinical outcomes.
摘要:
Pulmonary fibrosis represents the advanced phase of diverse pulmonary ailments, and at present, a definitive cure for these ailments is lacking. Furthermore, underlying mechanisms causative of these ailments remain elusive. Macrophages are immune cells that resist external stimuli in the early stages after birth. These cells can polarize into the classically (M1) and alternatively (M2) activated macrophages. When stimulated owing to the presence of toxic factors, M1 macrophages produce several pro-inflammatory factors, which mediate the inflammatory injury response of the alveolar tissue. The secretion of diverse growth factors by M2 macrophages contributes to the pathogenesis of aberrant alveolar structural fibrosis and remodeling. The abnormal activity of M2 macrophages is considered a critical factor in the formation of pulmonary fibrosis. In this mini-review, to highlight the clinical implications of research studies, we summarize the role and therapeutic targets of polarized subtypes of macrophages in pulmonary fibrosis and the role of targeting macrophages for the treatment of pulmonary fibrosis. M1-type macrophages and M2-type macrophages can transform into each other.M1-type macrophages participate in the early stage of pulmonary fibrosis by producing inflammatory cytokines, ROS and MMP.M2-type macrophages mediate abnormal alveolar tissue repair and tissue remodeling through the production of TGF-& beta;, FGF, and exosomes.Three therapeutic ideas were summarized in this paper: inhibition of the number and activity of lung macrophages, inhibition of M2-type macrophage polarization, inhibition of TGF-& beta; expression and its signalling pathway.
期刊:
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,2023年65(9):725-730 ISSN:1076-2752
通讯作者:
Shi, Y;Zheng, J
作者机构:
[Wen, Xilin; Shi, Yu; Xie, Yuxin; Li, Yichong; Fu, Ziwei] Chinese Acad Med Sci, Natl Clin Res Ctr Cardiovasc Dis, Fuwai Hosp, 12 Langshan Rd, Shenzhen 518057, Guangdong, Peoples R China.;[Xie, Yuxin; Xie, Hongwei; Fu, Ziwei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.;[Zheng, Jing; Zheng, J; Wang, Shuang] Shenzhen Hlth Dev Res & Data Management Ctr, 8 Yuanling Five St, Shenzhen 518106, Guangdong, Peoples R China.
通讯机构:
[Shi, Y ] C;[Zheng, J ] S;Chinese Acad Med Sci, Natl Clin Res Ctr Cardiovasc Dis, Fuwai Hosp, 12 Langshan Rd, Shenzhen 518057, Guangdong, Peoples R China.;Shenzhen Hlth Dev Res & Data Management Ctr, 8 Yuanling Five St, Shenzhen 518106, Guangdong, Peoples R China.
摘要:
Our findings further emphasize the health hazards of solid fuel for cooking and heating. This cohort study provides evidence for the effects of solid fuel use on hypertension among middle-aged and elderly Chinese adults, highlighting the importance of clean energy in reducing the risk of hypertension. ObjectiveThe aim of the study is to assess the association between solid fuel use for cooking or heating and the risk of hypertension among individuals older than 45 years.MethodsBaseline questionnaires were used to collect self-reported primary cooking and heating fuel usage. Outcomes were defined as the time of first diagnosis of hypertension. Data were analyzed using Cox proportional hazards models.ResultsSolid fuel use for cooking was associated with a higher risk of hypertension. The association between solid fuel for cooking and hypertension remained significant among residents in north China, individuals aged 45 to 65 years, urban residents, and nonsmokers. Solid fuel for heating was associated with a higher risk of hypertension only in South China.ConclusionsSolid fuel use may result in an increased risk of hypertension. Our findings further emphasize the health hazards of solid fuel for cooking and heating.
作者机构:
[Li, Qian; Xiao, Xilin; Liao, Lifu; Nie, Changming] Univ South China, Sch Chem & Chem Engn, Hunan Prov Key Lab Design & Applicat Actinide Comp, Hengyang 421001, Peoples R China.;[Yang, Jing] Hengyang Market Supervis Inspection & Testing Ctr, Hengyang City 421001, Peoples R China.;[Yu, Wenzhan] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[He, Liqiong; Zhou, Renlong] Univ South China, Sch Publ Hlth, Dept Publ Hlth & Lab Sci, Hengyang 421001, Peoples R China.;[Xiao, Xilin] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha, Peoples R China.
通讯机构:
[Xilin Xiao] S;School of Chemistry and Chemical Engineering, Hunan Province Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang 421001, P. R. China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, China
作者机构:
[Gao Xiao-yu; Qian Duo; Hu Cong-cong; Yang Sheng-yuan; Liu Zhi-yuan; Liu Bin; Su Wen-en; Yi Yu-xin] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
通讯机构:
[Yang, SY ] U;Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
关键词:
大豆蛋白金纳米簇;2,6-吡啶二羧酸;生物标志物;炭疽杆菌;荧光探针
摘要:
炭疽杆菌是高致病性病原微生物, 引起的炭疽病在我国属于乙类传染病, 因此建立操作简便、 灵敏准确的炭疽杆菌检测方法对预防和控制炭疽传播, 维护公共卫生安全至关重要。 该研究创新性地提出以绿色材料大豆蛋白为保护剂和还原剂, 采用微波加热法合成了一种具有强烈红色荧光发射的大豆蛋白金纳米簇(SPI-AuNCs)。 采用TEM、 UV-Vis、 FL、 XPS、 FTIR等方法表征了SPI-AuNCs的成功合成和部分特殊性能。 结果表明SPI-AuNCs呈球形, 粒径大小在1.8~3.2 nm范围内, 平均粒径为2.65 nm, 在500~550 nm范围内未出现表面等离子体共振峰; SPI-AuNCs的最大激发波长为370 nm, 最大发射波长为680 nm。 SPI-AuNCs的表面官能团主要有—NH、 —COOH、 —OH、 —SH等官能团, 元素的组成主要包括C、 N、 O、 S、 Au元素。 根据Cu2+与SPI-AuNCs表面基团通过配位作用形成非荧光复合物, 使荧光猝灭; 而2,6-吡啶二羧酸(DPA)与Cu2+具有更高的亲和力, 可将Cu2+从SPI-AuNCs表面竞争下来, 使荧光恢复, 据此建立了一种荧光“关-开”策略检测DPA的新方法。 在最佳实验条件下, 荧光恢复率(ΔF/F1)与DPA的浓度在1.15~70.0 μmol·L-1范围内呈良好的线性关系, 线性方程为ΔF/F1=0.011c+0.131, 相关系数r=0.991, 方法检出限为0.34 μmol·L-1。 同时, 通过加标回收实验研究了湖水和牛奶样品中DPA, 得到加标回收率在97.3%~103.6%, 表明了该方法在环境和食品样本DPA的检测中具有很大的应用潜力, 可以为环境监测和食品安全提供方法学支持。 Bacillus anthracis is a highly pathogenic microorganism. Anthrax is an infectious disease caused by Bacillus anthracis, classified as Class B of our country’s statutory reporting infectious diseases. Therefore, the establishment of simple operation, rapid and sensitive detection methods for Bacillus anthracis is vital for preventing and contralling the spread of anthrax and maintaining public health security. This study innovatively proposed to synthesize soy protein gold nanoclusters (SPI-AuNCs) with strong red fluorescence emission by microwave heating using the green material soy protein as a protective agent and reducing agent.TEM, XPS, FTIR, FL, and UV-Vis characterizations were used to verify successful synthesis of SPI-AuNCs. SPI-AuNCs are spherical, which the particle size is in the range of 1.8~3.2 nm, an average diameter of 2.65 nm, and no surface plasma resonance absorption from 500 to 550 nm. The maximum excitation wavelength of SPI-AuNCs is 370 nm, and the maximum emission wavelength appears at 680 nm. The surface functional groups of SPI-AuNCs mainly include —NH, —COOH, —OH, —SH, and the element composition includes C, N, O, S, Au elements. The fluorescence of SPI-AuNCs could be quenched by the coordination between Cu2+ and surface groups of SPI-AuNCs, while DPA has a stronger chelation effect with Cu2+, which could compete for Cu2+ from the surface of SPI-AuNCs and restore the fluorescence of SPI-AuNCs. Accordingly, a new method for DPA detection based on the fluorescent “off-on” strategy was established. Under the optimal experimental conditions, the fluorescence recovery efficiency (ΔF/F1) performs a good linear relationship with DPA concentration in the range of 1.15~70.0 μmol·L-1. The linear regression equation is ΔF/F1=0.011c+0.131 with high correlation coefficient (r=0.991), and the detection limit is 0.34 μmol·L-1. In addition, the spiking experiments of the DPA in lake water and milk samples were performed. The spiked recoveries were 97.3%~103.6%, indicating that this method has great application potential in DPA detection for environmental and food samples, and can provide methodological guidance for environmental monitoring and food safety.
通讯机构:
[Jianming Pan] I;[Lizhang Xu; Xiangheng Niu] S;School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
通讯机构:
[Yang, HF ] U;[Cai, R ] H;Hunan Univ, Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Coll Mat Sci & Engn,Coll Biol,Mol Sci & Biomed La, Changsha 410082, Hunan, Peoples R China.;Univ South China, Hunan Key Lab Typical Environm Pollut & Hlth Haza, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
摘要:
An ultralow-potential electrochemiluminescence (ECL) aptasensor has been designed for zearalenone (ZEN) assay based on a resonance energy transfer (RET) system with SnS2 QDs/g-C3N4 as a novel luminophore and CuO/NH2-UiO-66 as a dual-quencher. SnS2 QDs were loaded onto g-C3N4 nanosheets and enhanced the ECL luminescence via strong synergistic effects under an ultralow potential. The UV-vis absorption spectrum of CuO/NH2-UiO-66 exhibits considerable overlap with the ECL emission spectrum of SnS2 QDs/g-C3N4, an important consideration for the RET process. In order to stimulate RET, the ZEN aptamer and complementary DNA are introduced for conjugation between the donor and the acceptor. With the binding interaction between ZEN by its aptamer, CuO/NH2-UiO-66 is removed from the electrode surface, resulting in the inhibition of the RET system and an increase in the ECL signal. Under optimal conditions, the as-prepared aptasensor quantified ZEN from 0.5 mu g<middle dot>mL(-1)to 0.1 fg<middle dot>mL(-1 )with a low limit of detection of 0.085 fg<middle dot>mL(-1), and it exhibited good stability, excellent specificity, high reproducibility, and desirable practicality. The sensing strategy provides a method for mycotoxins assay to monitor food safety
作者机构:
[Liu, Jie; Yang, Shengyuan; Du, Wenfang; Tan, Yan; Li, Hong; Luo, Jie; Feng, Qianqian; Deng, Chenyi; Xiao, Fubing] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci,Hunan Key Lab Typ Environm, Hengyang 421001, Peoples R China.;[Du, Wenfang; Wu, Zhaoyang; Xiao, Fubing] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.;[Du, Wenfang] Binzhou Univ, Coll Biol & Environm Engn, Binzhou 256600, Peoples R China.
通讯机构:
[Fubing Xiao] H;Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
通讯机构:
[Hao Liang; Sheng-yuan Yang] D;Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China
摘要:
In this work, ovalbumin-stabilized gold nanoclusters(OVA-Au NCs) fluorescent nanoprobes were synthesized by microwave heating and applied to detect picric acid(PA). The nanoprobes emitted red fluorescence with the maximum fluorescence peak of 680 nm under the excitation...MORE In this work, ovalbumin-stabilized gold nanoclusters(OVA-Au NCs) fluorescent nanoprobes were synthesized by microwave heating and applied to detect picric acid(PA). The nanoprobes emitted red fluorescence with the maximum fluorescence peak of 680 nm under the excitation wavelength of 350 nm, and the Stokes shifts could be up to 330 nm which could effectively eliminate the interference of resonance scattering light. Compared with hydrothermal method, the synthesis method was simple and fast, and only took 50 s. Due to the absorption peak of PA overlapped with the emission peak of OVA-Au NCs in a large range, PA could selectively quench the fluorescence of OVA-Au NCs based on the inner filter effect(IFE) and a quick response time(1 min). Therefore, a new and sensitive method for PA monitoring was established. Under the optimal conditions, the concentration of PA demonstrated a satisfactory linear correlation with the fluorescence quenching degree ?F/F0of the sensing system in the range of 20-240 μmol/L with the detection limit of 6.4 μmol/L. The proposed method is simple, fast, accurate, and easy to realize real-time monitoring.FEWER
作者机构:
[Tang, Peng; Deng, Shuxiang; Chen, Limou; Feng, Shuidong; Cao, Mengyue; Yang, Fei; Tang, Yan] Univ South China, Sch Basic Med, Sch Publ Hlth, Hengyang Med Sch,Dept Epidemiol & Hlth Stat,Key La, Hengyang 421001, Peoples R China.;[Zhu, Lemei] Changsha Med Univ, Sch Publ Hlth, Changsha 410219, Peoples R China.;[Chen, Xiang] Cent South Univ, Xiangya Hosp, Hunan Engn Res Ctr Skin Hlth & Dis, Xiangya Clin Res Ctr Canc Immunotherapy,Dept Derma, Changsha 410008, Peoples R China.;[Shen, Minxue; Huang, Zhijun; Chen, Xiang] Furong Lab, Changsha 410008, Peoples R China.;[Huang, Zhijun] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Peoples R China.
通讯机构:
[Minxue Shen; Fei Yang] H;Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Department of Social Medicine and Health Management, Central South University, Changsha 410000, China<&wdkj&>Department of Epidemiology and Health Statistics, The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Basic Medicine, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Department of Social Medicine and Health Management, Central South University, Changsha 410000, China<&wdkj&>Furong Laboratory, Changsha 410008, China
关键词:
microcystins;triglyceride;cholesterol;lipoprotein;lipid profiles;dyslipidemia;cross-sectional study
摘要:
Abstract: Increasing evidence from experimental research suggests that exposure to microcystins (MCs) may induce lipid metabolism disorder. However, population-based epidemiological studies of the association between MCs exposure and the risk of dyslipidemia are lacking. Therefore, we conducted a population-based cross-sectional study involving 720 participants in Hunan Province, China, and evaluated the effects of MCs on blood lipids. After adjusting the lipid related metals, we used binary logistic regression and multiple linear regression models to examine the associations among serum MCs concentration, the risk of dyslipidemia and blood lipids (triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)). Moreover, the additive model was used to explore the interaction effects on dyslipidemia between MCs and metals. Compared to the lowest quartile of MCs exposure, the risk of dyslipidemia [odds ratios (OR) = 2.27, 95% confidence interval (CI): 1.46, 3.53] and hyperTG (OR = 3.01, 95% CI: 1.79, 5.05) in the highest quartile was significantly increased, and showed dose–response relationships. MCs were positively associated with TG level (percent change, 9.43%; 95% CI: 3.53%, 15.67%) and negatively associated with HDL-C level (percent change, −3.53%; 95% CI: −5.70%, −2.10%). In addition, an additive antagonistic effect of MCs and Zn on dyslipidemia was also reported [relative excess risk due to interaction (RERI) = −1.81 (95% CI: −3.56, −0.05)], and the attributable proportion of the reduced risk of dyslipidemia due to the antagonism of these two exposures was 83% (95% CI: −1.66, −0.005). Our study first indicated that MCs exposure is an independent risk factor for dyslipidemia in a dose–response manner. Keywords: microcystins; triglyceride; cholesterol; lipoprotein; lipid profiles; dyslipidemia; cross-sectional study Key Contribution: This study provides evidence that MCs exposure can increase the dyslipidemia risk in a dose–response manner. Serum MCs were positively associated with blood TG level and negatively associated with blood HDL-C level, which remains significant after adjustment for relevant covariates.
作者机构:
[童学智; 杨胜园] Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China;[陈东洋; 范翔; 张昊; 冯家力] Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China
通讯机构:
[Dongyang, C.] H;Hunan Provincial Center for Disease Control and PreventionChina