作者机构:
[Jiang, Jun; Chen, Xiang] Univ South China, Hengyang Med Sch, Postdoctoral Mobile Stn Basic Med Sci, Hengyang 421001, Peoples R China.;[He, Wei-Min; Huang, Xiao-Jun; He, WM] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构:
[He, WM ] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
摘要:
Benzoxazines are important structures in pharmaceuticals and functional molecules. We herein describe an electrochemical oxidative strategy for the synthesis of benzoxazines without transition-metal catalysts and external oxidants. In a undivided cell, a series of olefinic amides can be transferred to difluoromethylated benzoxazines with up to 87% yield via oxydifluoromethylation with CF2HSO2Na as the difluoromethylation reagent.
通讯机构:
[Lin, YW ; Zhang, Y ] U;Univ South China, Sch Chem & Chem Engn, Lab Optoelect Technol Low Dimens Nanomat, Hengyang, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Key Lab Prot Struct & Funct Univ Hunan Prov, Hengyang 421001, Peoples R China.
摘要:
The development of sensitive and real-time detection of human cytochrome c (Cyt c) has attracted significant interest since Cyt c plays an important role in programmed cell apoptosis and death, which has been considered an essential biomarker for early cancer diagnosis in human bodies. Herein, a self-powered photoelectrochemical (PEC) immunosensor based on Cu3SnS4 nanoflower is constructed for the ultra-sensitive and portable real-time detection of Cyt c. Systematic studies reveal that Cu3SnS4 has a large specific surface area and appropriate bandgap with excellent visible light absorption, which is beneficial for efficient PEC conversion. The prepared PEC immunosensor shows good reproducibility, high specificity, good storage stability, and excellent detection capability of Cyt c in clinical serum samples. The immunosensor shows dynamic linear detection of Cyt c in the range from 1 fM to 1000 nM along with an ultra-sensitive detection limit of 0.35 fM. Additionally, a portable real-time detection platform of Cyt c is designed, and the platform shows satisfactory linear correlation within the detection range from 1 fM to 1000 nM. We believe that this work provides a useful perspective for manufacturing portable ultra-sensitive and real-time PEC immunosensor for human Cyt c detection in early clinical diagnosis.
摘要:
Recently, ionic conductive organohydrogels (ICOs) have received widespread attention in wearable electronics. However, it remains challenging to combine reliable ionic conduction with good mechanical strength well, especially under extreme conditions. Herein, a novel ICO is produced by assembling polyvinyl alcohol with functionalized cellulose nanofibrils (CNFs) via a DMSO/H2O sol-gel process. A comprehensive study of the quaternized and carboxylated CNFs on ICOs is made. It is found that embedding of the latter can help ICOs to present excellent mechanical properties (tensile/compressive stress of 2.10/7.61 MPa), freezing tolerance (- 78 degrees C), and the highest electrical conductivity (3.23 S center dot m(-1)). Since all the primary alcohol carbons in the carboxylated CNFs have been thoroughly carboxylated, it is undoubted that their intermolecular attraction is sharply decreased to increase the counterion Na+ attraction, thus providing more hopping sites to enhance the ion transfer. Moreover, benefiting from these advantages, a human-interactive sensor based on the novel ICO is constructed to discern multiple human motions, including finger bending, wrist flexing, elbow bending, and walking. Overall, a facile yet versatile strategy is introduced that is expected to shed light on fabricating ICOs with all-around performance applicable in wearable electronics.
作者机构:
[Li, Qian; Xiao, Xilin; Liao, Lifu; Nie, Changming] Univ South China, Sch Chem & Chem Engn, Hunan Prov Key Lab Design & Applicat Actinide Comp, Hengyang 421001, Peoples R China.;[Yang, Jing] Hengyang Market Supervis Inspection & Testing Ctr, Hengyang City 421001, Peoples R China.;[Yu, Wenzhan] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[He, Liqiong; Zhou, Renlong] Univ South China, Sch Publ Hlth, Dept Publ Hlth & Lab Sci, Hengyang 421001, Peoples R China.;[Xiao, Xilin] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha, Peoples R China.
通讯机构:
[Xilin Xiao] S;School of Chemistry and Chemical Engineering, Hunan Province Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang 421001, P. R. China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, China
作者机构:
[Yan, Qi; Song, Jiaqi; Wang, Jiyan; Chang, Hongkai; Sun, Huanran; Xie, Fei; Zhang, Han; Sun, Mingming; Shan, Changliang; Wang, Yingzhi; Qiao, Yaya] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China.;[Li, Zhen; Li, Leilei] Jinan Univ, Biomed Translat Res Inst, Guangzhou 510632, Peoples R China.;[Lin, Shu-Hai; Niu, Yujia] Xiamen Univ, Innovat Ctr Cell Signaling Network, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China.;[Tan, Junzhen; Lai, Sizhen; Zhao, Huifang; Yang, Chenxin; Zhang, Shuai] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.;[Li, Yanping] Jining Med Univ, Inst Precis Med, Dept Pathol, Jining 272067, Peoples R China.
通讯机构:
[Lin, S.-H.] S;State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China
摘要:
Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein argi-nine methyltransferase 6 (PRMT6) is highly expressed in lung cancer and is required for cell metabolism, tumorigenicity, and cisplatin response of lung cancer. PRMT6 regulated the oxidative pentose phosphate pathway (PPP) flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phospho-gluconate dehydrogenase (6PGD) and a-enolase (ENO1). Furthermore, PRMT6 methylated R324 of 6PGD to enhancing its activity; while methylation at R9 and R372 of ENO1 promotes formation of active ENO1 dimers and 2-phosphoglycerate (2-PG) binding to ENO1, respectively. Lastly, targeting PRMT6 blocked the oxidative PPP flux, glycolysis pathway, and tumor growth, as well as enhanced the anti-tumor effects of cisplatin in lung cancer. Together, this study demonstrates that PRMT6 acts as a post -translational modification (PTM) regulator of glucose metabolism, which leads to the pathogenesis of lung cancer. It was proven that the PRMT6-6PGD/ENO1 regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy.(c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
摘要:
Glue! A green and practical one‐pot method for the electrochemical three‐component synthesis of tetrahydroimidazo[1,5‐a]quinoxalin‐4(5H)‐ones using cheap and environmentally benign paraformaldehyde as a C1 synthon, was developed. In this strategy, EtOH played dual roles (eco‐friendly solvent and waste‐free pre‐catalyst) and the in situ generated ethoxide promoted triple sequential deprotonations. Abstract A green and practical method for the electrochemical synthesis of tetrahydroimidazo[1,5‐a]quinoxalin‐4(5H)‐ones through the three‐component reaction of quinoxalin‐2(1H)‐ones, N‐arylglycines and paraformaldehyde was reported. In this strategy, EtOH played dual roles (eco‐friendly solvent and waste‐free pre‐catalyst) and the in situ generated ethoxide promoted triple sequential deprotonations.
摘要:
The conversion of superoxide radical (& BULL;O2 ) to hydrogen peroxide (H2O2) is critical in the photocatalytic for-mation of H2O2 via the sequential two-step single-electron oxygen reduction mechanism. Providing a high concentration of & BULL;O2  is an effective approach to promoting this process in terms of chemical kinetics. It is, however, extremely challenging to implement this idea in the photocatalytic solution due to the limited lifespan of & BULL;O2 . To this end, a concept about local & BULL;O2  enrichment catalyst surface was proposed in this study and achieved in an innovative PSI/C3N4 photocatalyst. The results of theoretical calculations and temperature-dependent photocatalytic studies indicate that PSI on the C3N4 surface can serve as a diffusion buffer for & BULL;O2 , capturing them through Van der Waals interactions and separating them by energy perturbations. As a result, a local enrichment of & BULL;O2  was established on the PSI/C3N4 surface during photocatalysis, strengthening the photocatalytic conversion of & BULL;O2  to H2O2, thus allowing the PSI/C3N4-4 photocatalyst to produce H2O2 at a rate of approximately 2.4 and 2.65 times greater than pure C3N4 under visible light and LED irradiation, respectively. This study presents a promising strategy for enhancing photocatalytic H2O2 production efficiency by selectively enriching & BULL;O2  on the catalyst surface.
期刊:
Journal of Cluster Science,2023年34(5):2373-2380 ISSN:1040-7278
通讯作者:
Yan-Ming Chen<&wdkj&>Xiao-Bo Nie
作者机构:
[Chen, Yan-Ming; Han, Jiao] Shenyang Univ Technol, Sch Petrochem Engn, Liaoyang 111003, Liaoning, Peoples R China.;[Nie, Xiao-Bo] Univ South China, Hengyang Med Coll, Sch Chem & Chem Engn, Postdoctoral Mobile Stn Basic Med Sci, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Yan-Ming Chen] S;[Xiao-Bo Nie] P;School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang, China<&wdkj&>Postdoctoral Mobile Station of Basic Medicine Sciences, Hengyang Medical College, School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
关键词:
Chemical reduction;Morphological structure;Plasmon absorption;Sodium oleate;Solvothermal synthesis
摘要:
Silver (Ag) nanocrystals are appealing due to their excellent antimicrobial properties. Synthesis of harmless Ag nanocrystals by low toxic reagents remains significant. Herein, an environmentally benign solvothermal process was applied to synthesize Ag nanocrystals in ethylene glycol (EG) dissolving silver nitrate and sodium oleate. Silver ions were reduced by EG to zero-valent Ag atoms that underwent nucleation and growth to form oleate-stabilized Ag nanocrystals. Multiple experimental parameters including the reaction time, temperature, concentration of Ag precursor, and the molar ratio of sodium oleate and silver nitrate were investigated to probe their effects on morphological structures and surface plasmon resonance (SPR) properties of resulting Ag nanocrystals. Results from UV-Vis absorption spectra and TEM images show that structural and SPR features of Ag nanocrystals are extremely sensitive to the reaction temperature as well as the molar ratio of sodium oleate and silver nitrate. Especially, two absorption bands appeared. The short wavelength (similar to 450 nm) represents the characteristic SPR of Ag nanospheres. While, the plasmon absorption at long wavelength (500-700 nm depending on reaction conditions) indicates the anisotropic or heterogeneous structures of Ag nanocrystals that maybe pave their potential applications in asymmetric catalysis, selective growth of coating materials, nanomedicine and optoelectronics.
期刊:
Chemical Communications,2023年59(19):2743-2746 ISSN:1359-7345
通讯作者:
Hu, Rong(hurong@usc.edu.cn);Qin, Anjun(msqinaj@scut.edu.cn);Tang, Ben Zhong(tangbenz@cuhk.edu.cn)
作者机构:
[Zhang, Guiquan; Qin, Anjun; Han, Pengbo; Hu, Rong; Yang, Xinzhe; Wang, Zhiming] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.;[Zhang, Guiquan; Qin, Anjun; Han, Pengbo; Hu, Rong; Yang, Xinzhe; Wang, Zhiming; Tang, Ben Zhong] South China Univ Technol, AIE Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China.;[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China.;[Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Hong Kong Branch, Clear Water Bay, Hong Kong, Peoples R China.;[Hu, Rong] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构:
[Rong Hu; Anjun Qin] S;[Ben Zhong Tang] C;State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China<&wdkj&>Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China<&wdkj&>State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
摘要:
A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature.
期刊:
New Journal of Chemistry,2023年47(30):14242-14248 ISSN:1144-0546
通讯作者:
Sen Liao<&wdkj&>Guoping Wang
作者机构:
[Liao, Sen; Zhang, Lilei; Li, Shiyu; Yue, Siyao; Wang, Guoping] School of Chemistry and Chemical Engineering, University of South China, Hengyang Hunan Province 421001, P. R. China
通讯机构:
[Sen Liao; Guoping Wang] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang Hunan Province 421001, P. R. China
摘要:
Si-CQDs with uniform particle size and good water solubility were synthesised using low-cost citric acid (CA) and aminopropyltriethoxysilane (APTEOS) as precursors. Si-CQDs were used as a novel fluorescent probe for sensitive and selective detection of mercury ions (Hg2+) by fluorescence quenching. Following the optimisation of the experimental conditions, the fluorescence intensity of Si-CQDs was found to be linearly dependent on the Hg2+ concentration ranging from 0.02 to 5.0 μM with the limit of detection as low as 0.015 μM. A fluorescence resonance energy transfer (FRET) effect between Si-CQDs and Rhodamine B (RhB) was also observed, and it was found that Si-CQDs can be used as fluorescence donors and RhB as fluorescence receptors. On this basis, a ratiometric fluorescent probe (Si-CQDs/RhB) was constructed for Hg2+ detection. When the Hg2+ concentration was 1.0–80.0 μM, the fluorescence intensity ratio (I540nm/I440nm) of Si-CQDs/RhB exhibited a good linear relationship with Hg2+ concentration and the detection limit was 0.6 μM. A wide range of Hg2+ detection was ultimately achieved in real samples.
摘要:
The new two‐dimensional (2D) polyoxometalate clusterphene (POMCene) with a similar hexagonal structure to graphene is synthesized and applied for photoelectrochemical (PEC)‐type photodetection for the first time. Such a 2D POMCene‐based photodetector shows good photodetection capability and excellent long‐term stability (over 3 months) in a harsh environment, indicating the great potential of 2D POMCene for practical applications. Abstract Exploration of novel two–dimensional (2D) nanomaterials with desired properties using a controlled approach remains one of the major challenges ahead. Clusterphene, the newly emerged 2D formation of self‐assembled clusters, exhibits a comparable structure to graphene with intriguing physicochemical features, which are applied in several scientific disciplines. Herein, it is demonstrated that polyoxometalate clusterphene (POMCene) is a promising 2D nanomaterial for photoelectrochemical (PEC) photodetection. The photodetection performance of POMCene can be subtly tuned by adjusting external conditions like bias voltage, electrolyte, and incident wavelength. A photocurrent of 1.88 µA cm‒2, a responsivity of 2.26 µA W‒1, a detectivity of 5.65 × 109 Jones, and a fast response speed of 0.02 s along with good long‐term stability can be achieved. It is believed that this research can pave a new direction for the future development of 2D POMCene in high‐performance optoelectronic devices.
摘要:
As a widely used carbamate pesticide, carbaryl not only had neurotoxicity by inhibiting the activity of acetylcholinesterase, but also had environmental hormone effects, so it is important to establish a convenient and sensitive method for the detection of carbaryl. An original photoresponsive molecularly imprinted electrochemical sensor (MIP-MGCE) was fabricated from glassy carbon electrode (GCE) as the substrate, 5-[(4-(methacryloyloxy)phenyl)diazenyl]isophthalic acid (MAPDIA) as the functional monomer and carbaryl as the template, where a layer of molecular imprinting film was constructed and overattached on the surface of GCE modified by carboxylic multi-walled carbon nanotube-chitosan (MWCNT-CT) composite with the large specific surface area and good conductivity. The constructed sensors were characterized by FT-IR and cyclic voltammetry (CV). The ratio of template molecule to monomer, elution time, and incubation time were optimized to be 1:4, 2 min and 6 min, respectively. By the differential pulse voltammetry (DPV) method, the experimental amperometric curve of MIP-MGCE had favorable linear relationship. The linear equation was Delta I = 190.2933C + 1.9824 with R-2 = 0.9865 when in the carbaryl concentration range of 0.0035-0.1100 mu mol L-1, and the linear equation became Delta I = 2.8940C + 25.4230 with R-2 = 0.9917 when in the range of 0.1100-13.9600 mu mol L-1. The detection limit of the above method was 0.0011 mu mol L-1 (S/N = 3). The prepared sensor was also applied to the detection of carbaryl in tap water samples, and the results showed it had not only a better recovery rate of 97.00% with 3.43% of RSD but also excellent selectivity and repeatability.
通讯机构:
[Huijun Liu] D;Department of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, China
关键词:
MXene;GSH;Redox-responsive;PEG;Drug delivery system
摘要:
MXene has a large surface area, which gives medicinal drug molecules enough anchor sites. This property can be utilized to design incredibly effective intracellular drug delivery systems. In this work, a non-toxic and safe Ti3C2Tx materials was chosen in MXene. Ti3C2Tx MXene was decorated with Methoxy Polyethylene Glycol (PEG) by a linker cystamine dihydrochloride disulfide bonds (-SS-). The DOX delivery system of Ti3C2Tx MXene modified by PEG was constructed. To further examine the system's potential as a cancer treatment, in vitro tests were conducted. The outcomes demonstrated the potential of PEG-modified MXene nanosheets as nanocarriers for the delivery of DOX to tumors because they had excellent biocompatibility and no discernible side effects. In contrast to the free DOX, the drug carrier MXene-SS-PEG@DOX was more toxic to human hepatoma cells (HepG2) and less toxic to healthy macrophages (RAW264.7). DOX is released at a rate of 84.4% in PBS solution with a pH of 4.50 and a GSH concentration of 10 mM, which is higher than that of normal cells' physiological environment. The redox response drug delivery system has been investigated in this work, and the findings indicate that the drug delivery system is a promising contender for both drug delivery and stimulus response release.
作者:
Jun Zhao;Yuezhu Wang;Chenchen Feng;Mingxue Yin;Yu Gao;...
期刊:
Computational and Structural Biotechnology Journal,2023年 ISSN:2001-0370
通讯作者:
Jian Zhang<&wdkj&>Jiang Zhu
作者机构:
[Yu Gao; Bo Ai; Jian Zhang; Jiang Zhu] School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing, 163319, China;The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;School of Computer, University of South China, Hengyang, Hunan, 421001, China;The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;Hunan Provincial Base for Scientific and Technological Innovation Cooperation, University of South China, Hengyang, Hunan, 421001, China
通讯机构:
[Jian Zhang; Jiang Zhu] S;School of Medical Informatics, Daqing Campus, Harbin Medical University. Daqing, 163319, China
关键词:
Single cell integration database;Cell heterogeneity;Multi-method automatic cell-type annotation;Cell to cell communication
摘要:
Single-cell RNA sequencing (scRNA-seq), which profiles gene expression at the cellular level, has effectively explored cell heterogeneity and reconstructed developmental trajectories. With the increasing research on diseases and biological processes, scRNA-seq datasets are accumulating rapidly, highlighting the urgent need for collecting and processing these data to support comprehensive and effective annotation and analysis. Here, we have developed a comprehensive Single-Cell transcriptome integration database for human and mouse (SCInter, https://bio.liclab.net/SCInter/index.php), which aims to provide a manually curated database that supports the provision of gene expression profiles across various cell types at the sample level. The current version of SCInter includes 115 integrated datasets and 1016 samples, covering nearly 150 tissues/cell lines. It contains 8,016,646 cell markers in 457 identified cell types. SCInter enabled comprehensive analysis of cataloged single-cell data encompassing quality control (QC), clustering, cell markers, multi-method cell type automatic annotation, predicting cell differentiation trajectories and so on. At the same time, SCInter provided a user-friendly interface to query, browse, analyze and visualize each integrated dataset and single cell sample, along with comprehensive QC reports and processing results. It will facilitate the identification of cell type in different cell subpopulations and explore developmental trajectories, enhancing the study of cell heterogeneity in the fields of immunology and oncology.
摘要:
2D violet phosphorus (VP) nanosheets are utilized as self‐powered photoelectrochemical‐type photodetector. The results indicate that VP nanosheets achieve preferable photo‐response activities from ultraviolet to visible region along with good chemical and environmental stability. Abstract Violet phosphorus (VP) is a stable layered van der Waals phosphorus allotrope with unique electronic and optoelectronic properties. In this study, 2D VP nanosheets (NSs) are prepared by liquid phase exfoliation (LPE) method under ambient conditions. The prepared VP NSs are characterized and utilized for photoelectrochemical (PEC)‐type photodetector (PD). The systematic PEC measurements reveal that the as‐prepared VP‐based PD shows tunable photo‐response activities from ultraviolet to visible region. A current density of 0.52 µA cm−2, a photo‐responsivity of 31.70 µA W−1, and a detectivity of 7.92 × 1010 Jones can be obtained in 1.0 m KOH under 350 nm irradiation at 0 V, revealing the good self‐powered capability of VP‐based PD. Furthermore, the cycle and time stability tests exhibit the good chemical and environmental stability of the as‐prepared PD via processing 10 000 s on/off switching and placing after one month. It is expected that this work can offer an understanding of a PEC‐type VP NSs‐based PD, and highlight the further promising applications of 2D VP NSs for other optoelectronic devices.
摘要:
Abstract: The efficient removal of radionuclide uranium is crucial for sustainable nuclear energy and achieving a zero-carbon loop. In this study, we synthesized MXene/MnO2 nanocomposites and evaluated their ability to adsorb and reduce uranium. The results showed that the nanocomposites achieved a uranium removal rate of 99% and an adsorption capacity of 696 mg/g. Adsorption experiments were conducted under different conditions, including pH, cation, anion, and humic acid, and the uranium removal rate by the composite remained high at 91%, 70%, and 60% under the influence of pH = 4.97, 1.0 mM CaCl2, and 20 mg/L humic acid, respectively. The XRD and SEM analyses revealed that the uranium element was removed by the reduction and fixation of the composite material. These findings indicate that the MXene/MnO2 composite is an effective adsorption cleaning agent for the purification of radioactive nuclear wastewater, which has significant implications for pollution control. Keywords: MXene; MnO2; nanocomposites; adsorption performance; uranium