通讯机构：
[Xia, YF ] U;Univ South China, Coll Nucl Sci & Technol, Hengyang 421001, Peoples R China.
摘要：
The sol-gel technique is used in this paper to prepare Cr-doped BiFeO3 . The magnetism of BiFe1−xCrxO3 with a distorted rhombohedral perovskite structure has been studied for x=0.1 . X-ray diffraction analysis reveals that the sample is rhombohedral with the space group R3C and contains some impurity phases. The Mössbauer spectra at 300 and 500 K are used to determine the magnetic and impurity phase proportion as well as the valence state, electric field gradient, internal magnetic field, and electron cloud distribution of Fe3+ions in BiFe0.9Cr0.1O3 . The magnetic properties of BiFe0.9Cr0.1O3 are complex. Through the zero-field-cooled/field-cooled magnetization curve, the magnetism of BiFe0.9Cr0.1O3 is analyzed. According to the first-order differential of magnetization to temperature, the Néel temperature is determined to be ∼134K . It is speculated that a partial relaxation structure may exist in the system. Then the Heisenberg model simulation and experimental data are approximated using the particle swarm optimization algorithm to further analyze the magnetism and calculate the more precise phase transformation temperature. It has been determined that the exchange constants for cubic structure and relaxation structure are JFe−Cr=6.75meV, JFe−Fe=−6.13meV, JFe−Fe′=−1.16meV , and JFe−Cr′=−1.54meV . The cubic and relaxation structures contribute 0.71 and 0.29 to magnetism, respectively. According to the Heisenberg model, the Curie temperature should be ∼606K , and the Néel temperature should be ∼116K . The ratio of the Curie temperature to the Weiss constant is significantly >5, implying that the entire spin system is in a state of high frustration.
摘要：
Marine dinoflagellates Alexandrium are known to produce saxitoxin (STX) and cause paralytic shellfish poisoning (PSP) which can result in mortality in human. SxtA is considered a core gene for the biosynthesis of STX. However, its gene coding structure and evolutionary history have yet to be fully elucidated. Here, we determined the full-length sequences of sxtA cDNA and genomic coding regions from two toxic dinoflagellates, Alexandrium catenella (LIMS-PS-2645 and LIMS-PS-2647) and A. pacificum (LMBE-C4), characterised their domain structures, and resolved evolutionary events. The sxtA gene was encoded on the genome without introns, and was identical in length (4002 bp) between two A. catenella strains, but their sequences differed from A. pacificum (5031 bp). SxtA consists of four domains, sxtA1, sxtA2, sxtA3, and sxtA4; however, A. pacificum has an extra domain TauD near sxtA1. Each domain had >64.4% GC content, with the highest being 71.6% in sxtA3. Molecular divergence was found to be significantly higher in sxtA4 than in the other domains. Phylogenetic trees of sxtA and separate domains showed that bacteria diverged earliest, followed by non-toxic, toxic cyanobacteria, toxic dinoflagellates. While sxtA domains in Alexandrium were similar to the PKS-like structure with the conserved sxtA1, sxtA2, and sxtA3. PKS_KS may be replaced by sxtA4 in toxic Alexandrium. These suggest that sxtA in Alexandrium may have evolved by acquiring specific domains, whose modification and complexity markedly affect toxin biosynthesis.
期刊：
EUROPEAN PHYSICAL JOURNAL A,2022年58(9):1-19 ISSN：1434-6001
通讯作者：
Xiao-Hua Li
作者机构：
[Zhu, De-Xing; Li, Xiao-Hua; Xu, Yang-Yang; Chen, Xun] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Wu, Xi-Jun] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[He, Biao] Cent South Univ, Coll Phys & Elect, Changsha 410083, Peoples R China.;[Li, Xiao-Hua] Univ South China, Natl Exemplary Base Int Sci & Tech Collaborat Nuc, Hengyang 421001, Peoples R China.;[Li, Xiao-Hua] Univ South China, Cooperat Innovat Ctr Nucl Fuel Cycle Technol & Eq, Hengyang 421001, Peoples R China.
通讯机构：
[Xiao-Hua Li] S;School of Nuclear Science and Technology, University of South China, Hengyang, People’s Republic of China<&wdkj&>National Exemplary Base for International Sci and Tech. Collaboration of Nuclear Energy and Nuclear Safety, University of South China, Hengyang, People’s Republic of China<&wdkj&>Cooperative Innovation Center for Nuclear Fuel Cycle Technology and Equipment, University of South China, Hengyang, People’s Republic of China<&wdkj&>Key Laboratory of Low Dimensional Quantum Structures and Quantum Control, Hunan Normal University, Changsha, People’s Republic of China
摘要：
Based on the Hatsukawa formula (Hatsukawa et al. in Phys Rev C 42:674, 1990), modifying the coefficient F(Z) and considering the blocking effect of unpaired nucleons, in our previous work (Xu and Liu in Eur Phys J A 58:16, 2022) we proposed an improved semi-empirical formula for evaluating the favored
$$\alpha $$
decay half-lives. In this work, considering the contribution of centrifugal potential, we generalize this formula to unfavored
$$\alpha $$
decay and propose a unified formula for
$$\alpha $$
decay half-lives. Using this formula, we systematically calculate the unfavored
$$\alpha $$
decay half-lives of 130 odd-A and 78 odd–odd nuclei with the corresponding root-mean-square (rms) deviations being 0.503 and 0.603, respectively. Meanwhile the rms deviation of
$$\alpha $$
decay half-lives for all the 700 nuclei taken from NUBASE2020 is only 0.380. Moreover, we extend this formula to predict the
$$\alpha $$
decay half-lives of 144 even–even, odd-A and odd–odd nuclei with Z = 117, 118, 119 and 120. For comparison, the unitary Royer formula (DZR) (Deng et al. in Phys Rev C 101:034307, 2020) proposed by Deng et al. and the modified universal decay law (MUDL) (Soylu and Qi in Nucl Phys A 1013:122221, 2021) proposed by Soylu et al. are also used. The predictions of these formulas are basically consistent with each other.
摘要：
BACKGROUND: This meta-analysis was performed to investigate the effects of nicotinamide adenine dinucleotide (NAD+) precursor supplementation on glucose and lipid metabolism in human body. METHODS: PubMed, Embase, CENTRAL, Web of Science, Scopus databases were searched to collect clinical studies related to the supplement of NAD+ precursor from inception to February 2021. Then the retrieved documents were screened, the content of the documents that met the requirements was extracted. Meta-analysis and quality evaluation was performed detection were performed using RevMan5.4 software. Stata16 software was used to detect publication bias, Egger and Begg methods were mainly used. The main research terms of NAD+ precursors were Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Nicotinic Acid (NA), Nicotinamide (NAM). The changes in the levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and fasting blood glucose were mainly concerned. RESULTS: A total of 40 articles were included in the meta-analysis, with a sample of 14,750 cases, including 7406 cases in the drug group and 7344 cases in the control group. The results of meta-analysis showed that: NAD+ precursor can significantly reduce TG level (SMD = - 0.35, 95% CI (- 0.52, - 0.18), P < 0.0001), and TC (SMD = - 0.33, 95% CI (- 0.51, - 0.14), P = 0.0005), and LDL (SMD = - 0.38, 95% CI (- 0.50, - 0.27), P < 0.00001), increase HDL level (SMD = 0.66, 95% CI (0.56, 0.76), P < 0.00001), and plasma glucose level in the patients (SMD = 0.27, 95% CI (0.12, 0.42), P = 0.0004). Subgroup analysis showed that supplementation of NA had the most significant effect on the levels of TG, TC, LDL, HDL and plasma glucose. CONCLUSIONS: In this study, a meta-analysis based on currently published clinical trials with NAD+ precursors showed that supplementation with NAD+ precursors improved TG, TC, LDL, and HDL levels in humans, but resulted in hyperglycemia, compared with placebo or no treatment. Among them, NA has the most significant effect on improving lipid metabolism. In addition, although NR and NAM supplementation had no significant effect on improving human lipid metabolism, the role of NR and NAM could not be directly denied due to the few relevant studies at present. Based on subgroup analysis, we found that the supplement of NAD+ precursors seems to have little effect on healthy people, but it has a significant beneficial effect on patients with cardiovascular disease and dyslipidemia. Due to the limitation of the number and quality of included studies, the above conclusions need to be verified by more high-quality studies.
期刊：
Journal of Surgical Oncology,2022年126(8):1396-1402 ISSN：0022-4790
通讯作者：
Long-Qi Chen
作者机构：
[Shang, Qi-Xin; Wang, Wen-Ping; Gu, Yi-Min; Yuan, Yong; Yang, Yu-Shang; Zhang, Han-Lu; Chen, Long-Qi] Sichuan Univ, West China Hosp, Dept Thorac Surg, 37 Guoxue Alley, Chengdu 610041, Peoples R China.;[Shi, Gui-Dong] North Sichuan Med Coll, Affiliated Hosp, Dept Cardiothorac Surg, Nanchong, Peoples R China.;[Yan, Cheng-Yi] Univ South China, Changsha Cent Hosp, Dept Thorac Surg, Changsha, Peoples R China.
通讯机构：
[Long-Qi Chen ] D;Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, China
关键词：
adjuvant therapy;esophagectomy;prognostic factor;small cell carcinoma of the esophagus;stage
摘要：
BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in survival were analyzed using the Kaplan-Meier method and log-rank test. The prognostic factors were identified using univariate and multivariate analyses. RESULTS: A total of 69 patients were included. Multivariate analysis showed that TNM stage (hazard ratio [HR]: 4.10, 95% confidence interval [CI]: 1.57-10.75, p = 0.004) and adjuvant therapy (HR: 0.28, 95% CI: 0.16-0.51, p < 0.001) were independent prognostic factors. Stage I, stage IIA, and stage IIB disease were merged into the surgery response disease (SRD), whereas stage III disease into the surgery nonresponse disease (SNRD). The SRD group had significantly improved survival compared to the SNRD group (HR: 0.33, 95% CI: 0.19-0.58, p < 0.001). In addition, adjuvant therapy increased survival benefit in the SNRD group (p < 0.001) but not in the SRD group (p = 0.061). CONCLUSIONS: Surgery alone appears to be adequate for disease control in the SRD group, whereas multimodality therapy was associated with improved survival in the SNRD group.
期刊：
EUROPEAN PHYSICAL JOURNAL A,2022年58(12):1-15 ISSN：1434-6001
通讯作者：
Xiao-Hua Li
作者机构：
[Zhu, De-Xing; Luo, Song; Li, Xiao-Hua; Xu, Yang-Yang] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[He, Biao] Cent South Univ, Coll Phys & Elect, Changsha 410083, Peoples R China.;[Chu, Peng-Cheng] Qingdao Univ Sci & Technol, Sch Math & Phys, Qingdao 266033, Peoples R China.;[Li, Xiao-Hua] Univ South China, Natl Exemplary Base Int Sci & Technol, Collaborat Nucl Energy & Nucl Safety, Hengyang 421001, Peoples R China.;[Li, Xiao-Hua] Univ South China, Cooperat Innovat Ctr Nucl Fuel Cycle Technol & Equ, Hengyang 421001, Peoples R China.
通讯机构：
[Xiao-Hua Li] S;School of Nuclear Science and Technology, University of South China, Hengyang, People’s Republic of China<&wdkj&>National Exemplary Base for International Science and Technology, Collaboration of Nuclear Energy and Nuclear Safety, University of South China, Hengyang, People’s Republic of China<&wdkj&>Cooperative Innovation Center for Nuclear Fuel Cycle Technology and Equipment, University of South China, Hengyang, People’s Republic of China<&wdkj&>Key Laboratory of Low Dimensional Quantum Structures and Quantum Control, Hunan Normal University, Changsha, People’s Republic of China
摘要：
In the present work, considering the blocking effect of unpaired nucleons and the orbital angular momentum taken away by the emitted
$$\alpha $$
particle, we put forward an improved Geiger-Nuttall law to calculate
$$\alpha $$
-decay half-lives of heavy and superheavy nuclei. There are three adjustable parameters in this formula, whose values are obtained by fitting experimental
$$\alpha $$
decay half-lives of 216 nuclei ranging from Z = 90 to Z = 118 with N
$$\ge $$
130 from the ground state and/or isomeric state. The calculated results are in good agreement with the experimental data. The corresponding root-mean-square (rms) are 0.301, 0.587 and 0.541 for 65 even–even, 116 odd-A and 35 odd–odd nuclei, respectively. For comparison, the Royer formula proposed by G. Royer [J. phys. G 26, 1149(2000)], Viola-Seaborg-Sobiczewski formula (VSS) proposed by A. Sobiczewski et al. [J. Inorg. Nucl. Chem 28, 741(1966)] and Sobiczewski-Parkhomenko formula (SP) proposed by A. Parkhomenko et al. [Acta. Phys. Pol. B 36, 3095(2005)] are also used. In addition, this improved formula is extended to predict
$$\alpha $$
-decay half-lives for nuclei with Z = 117, 118, 119 and 120. The corresponding predictions of these formulae are basically consistent with each other.
作者机构：
[Lei, Xiaoyong; Liu, Songbin; Zhang, Yuan; Wu, Xin; Tang, Guotao; Peng, Junmei; Liu, Chang; Cao, Xuan] Univ South China, Sch Pharm, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.;[Lei, Xiaoyong; Liu, Songbin; Zhang, Yuan; Wu, Xin; Tang, Guotao; Peng, Junmei; Liu, Chang; Cao, Xuan] Collaborat Innovat Ctr Mol Targeted New Drug Res H, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Junmei Peng] D;Department of Pharmacy, School of Pharmacy, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Collaborative Innovation Center for Molecular Targeted New Drug Research in Hunan Province, Hengyang, Hunan 421001, China
摘要：
Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal maintenance family of proteins that mainly regulates DNA replication and the cell cycle and is involved in regulating cancer cell proliferation in various cancers. Previous studies have reported that MCM2 plays a pivotal role in cell proliferation and cancer development. However, few articles have systematically reported the pathogenic roles of MCM2 across cancers. Therefore, the present pan-cancer study was conducted. Various computational tools were used to investigate the MCM2 expression level, genetic mutation rate, and regulating mechanism, immune infiltration, tumor diagnosis and prognosis, therapeutic response and drug sensitivity of various cancers. The expression and function of MCM2 were examined by Western blotting and CCK-8 assays. MCM2 was significantly upregulated in almost all cancers and cancer subtypes in The Cancer Genome Atlas and was closely associated with tumor mutation burden, tumor stage, and immune therapy response. Upregulation of MCM2 expression may be correlated with a high level of alterations rate. MCM2 expression was associated with the infiltration of various immune cells and molecules and markedly associated with a poor prognosis. Western blotting and CCK-8 assays revealed that MCM2 expression was significantly upregulated in melanoma cell lines. Our results also suggested that MCM2 promotes cell proliferation in vitro by activating cell proliferation pathways such as the Akt signaling pathways. This study explored the oncogenic role of MCM2 across cancers, provided data on the underlying mechanisms of these cancers for further research and demonstrated that MCM2 may be a promising target for cancer immunotherapy.
期刊：
FRONTIERS IN SURGERY,2022年9:862716 ISSN：2296-875X
通讯作者：
Li, Y.
作者机构：
[Tong, Wenjuan; Yang, Shuangjian; Li, Yi] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gynecol & Obstet, Hengyang, Peoples R China.
通讯机构：
[Li, Y.] T;The First Affiliated Hospital, Department of Gynecology and Obstetrics, Hengyang Medical School, University of South China, Hengyang, China
关键词：
invasion ability;placental trophoblast cells;preeclampsia;transcription factor Twist1;urine protein
摘要：
Cardiac hypertrophy is a leading cause of cardiac morbidity and mortality worldwide. Apelin is the endogenous ligand for the G protein-coupled receptor, APJ. Previously, we have revealed that apelin-13 can induce cardiomyocyte hypertrophy by activating the autophagy pathway. However, the precise mechanism through which apelin-13 regulates reticulophagy to participate in cardiomyocyte hypertrophy remains unclear. Herein, we observed that apelin-13-induced cardiomyocyte hypertrophy by activating FAM134B-dependent reticulophagy via the Pannexin-1/P2X7 signal pathway. Furthermore, we found that apelin-13 stimulated the opening of Pannexin-1 hemichannel and increased extracellular ATP (eATP) levels, which activated the P2X7 purinergic receptor. Activation of the Pannexin-1/eATP/P2X7 axis subsequently led to FAM134B-dependent reticulophagy. Moreover, inhibition of the Pannexin-1/P2X7 axis and FAM134B-dependent reticulophagy reversed apelin-13-induced cardiomyocyte hypertrophy. Based on our present findings, apelin-13/APJ induces cardiomyocyte hypertrophy by activating the Pannexin-1/P2X7 axis and FAM134B-dependent reticulophagy.
作者机构：
[Luo, Fangzhen; Li, Zhongyu; Su, Shengmei; Lei, Wenbo; Zhao, Lanhua; Chen, Chaoqun; Chen, Lili; Wen, Yating] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.;[Luo, Fangzhen] Hunan Polytech Environm & Biol, Coll Med Technol, Hengyang, Peoples R China.;[Huang, Qiulin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Qiulin Huang] T;[Zhongyu Li] I;The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, P. R. China<&wdkj&>Institute of Pathogenic Biology, Hengyang Medical School, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, P. R. China
摘要：
Persistent infection of Chlamydia trachomatis is thought to be responsible for the debilitating sequelae of blinding trachoma and infertility. Inhibition of host cell apoptosis is a persistent C. trachomatis infection mechanism. ZEB1-AS1 is a long non-coding RNA (lncRNA), which was up-regulated in persistent C. trachomatis infection in our previous work. In this study, we investigated the role of ZEB1-AS1 in persistent infection and the potential mechanisms. The results showed that ZEB1-AS1 was involved in the regulation of apoptosis, and targeted silencing of ZEB1-AS1 could increase the apoptosis rate of persistently infected cells. Mechanically, interference ZEB1-AS1 caused an apparent down-regulation of the Bcl-2/Bax ratio and the repression of the mitochondrial membrane potential with the remarkable release of cytochrome c, resulting in the significant elevation level of caspase-3 activation. Meanwhile, the luciferase reporter assay confirmed that ZEB1-AS1 acted as a sponge for miR-1224-5p to target MAP4K4. The regulatory effect of miR-1224-5p/MAP4K4 on persistent infection-induced antiapoptosis was regulated by ZEB1-AS1. In addition, ZEB1-AS1 inhibited the apoptosis of Chlamydia-infected cells by activating the MAPK/ERK pathway. In conclusion, we found a new molecular mechanism that the ZEB1-AS1/miR-1224-5p/MAP4K4 axis contributes to apoptosis resistance in persistent C. trachomatis infection. This work may help understand the pathogenic mechanisms of persistent C. trachomatis infection and reveal a potential therapeutic strategy for its treatment.
通讯机构：
[Dongdong Xia; Chengyi Xiao; Weiwei Li] B;Beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China<&wdkj&>Beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China<&wdkj&>Institute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang 330096, P. R. China
关键词：
N-annulated perylene bisimides;double-cable polymers;molecular symmetry;phase separation;single-component organic solar cells
摘要：
The wide application of LaMn0.5Fe0.5O3 perovskite is due to its very complex magnetic and structural properties. Orthorhombic perovskite structure samples were prepared by sol-gel method. The system has a special spin glass state (Ne'el temperature below freezing temperature). Therefore, there is a transition for the main magnetic phase from strong antiferromagnetism to ferrimagnetism and finally to superparamagnetism as the temperature in-creases. The typical ferromagnetic and antiferromagnetic competing exchange bias phenomenon appears in the M -H curve at 5 K. We have simulated the thermal and magnetic characteristics of the system through the XYZ model and particle swarm optimization and obtained accurate anisotropy parameters. The transitions of the Mossbauer spectra at different temperatures reflect the changes in the macroscopic magnetic properties of the system. Finally, we can explain the relaxation peak behavior of Mossbauer spectra well by the relationship between the relaxation hyperfine field and temperature. This study will provide a good illustration and reference for the magnetic nature of strongly magnetic disordered LaMn0.5Fe0.5O3 systems.
