期刊：
MINI-REVIEWS IN MEDICINAL CHEMISTRY,2024年24(6):642-663 ISSN：1389-5575
作者机构：
[Peng, Junmei Peng; Lei, Xiaoyong; Huang, Honglin; Yang, Jun; Zhang, Yuan; Wu, Xin; Sun, Xueyan; Tang, Guotao; Liu, Chang] Department of Pharmacy, School of Pharmacy, Hengyang Medical School, Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, 421001, China
摘要：
Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. According to the American Cancer Society's 2021 cancer data report, new cases of CML account for about 15% of all leukemias. CML is generally divided into three stages: chronic phase, accelerated phase, and blast phase. Nearly 90% of patients are diagnosed as a chronic phase. Allogeneic stem cell transplantation and chemotherapeutic drugs, such as interferon IFN-α were used as the earliest treatments for CML. However, they could generate obvious side effects, and scientists had to seek new treatments for CML. A new era of targeted therapy for CML began with the introduction of imatinib, the first-generation BCR-ABL kinase inhibitor. However, the ensuing drug resistance and mutant strains led by T315I limited the further use of imatinib. With the continuous advancement of research, tyrosine kinase inhibitors (TKI) and BCR-ABL protein degraders with novel structures and therapeutic mechanisms have been discovered. From biological macromolecules to classical target protein inhibitors, a growing number of compounds are being developed to treat chronic myelogenous leukemia. In this review, we focus on summarizing the current situation of a series of candidate small-molecule drugs in CML therapy, including TKIs and BCR-ABL protein degrader. The examples provided herein describe the pharmacology activity of small-molecule drugs. These drugs will provide new enlightenment for future treatment directions.
摘要：
Reconstruction of pressure-temperature-time (P-T-t) path of volumetrically-dominant orthogneisses in deeply subducted continental crusts is challenging due to their simple amphibolite-facies mineral assemblages. To provide new insights into this issue, a detailed study of mineral inclusions, trace elements and U-Pb ages within robust zircon containers, together with titanite U-Pb dating and petrology were conducted on ultrahigh-pressure (UHP) orthogneisses from the northern Sulu belt. The following P-T-t conditions of three metamorphic stages were constrained: (i) cathodoluminescence (CL)-grey zircon cores (ca. 238-237 Ma) with flat heavy rare earth element (HREE) patterns include garnet, phengite and omphacite that yield estimated P-T conditions of 2.3-2.8 GPa/730-800 degrees C, corresponding to prograde high-pressure (HP) metamorphism before the UHP peak. (ii) CLdark zircon mantles (ca. 224 Ma) contain multiphase solid inclusions of plagioclase +K-feldspar + quartz and show extremely low Th/U ratios (<= 0.08) and negative Eu anomalies, demonstrating their crystallization from hydrous melt at 2.0-1.8 GPa/890-820 degrees C during HP eclogite-facies exhumation. In addition, titanite grains are characterized by high LREE contents (1939-5239 ppm), Th/U ratios (0.37-0.81) and crystallization temperatures (830-801 degrees C), suggesting their peritectic origin. The lower intercept age (220 +/- 4 Ma) of titanite is broadly consistent with the ages of the zircon mantles, indicating that they both crystallized from the melt at the same stage. (iii) CL-bright zircon rims (ca. 212-211 Ma) preserve low-pressure mineral inclusions of plagioclase, Kfeldspar and quartz, and they show low Th/U ratios (0.03-0.12) and steep HREE patterns with negative Eu anomalies, witnessing amphibolite-facies overprinting at 1.0-0.8 GPa/610-550 degrees C. Combined with the metamorphic peak conditions of 3.2 GPa/840 degrees C at ca. 232 Ma constrained by previous studies from the same area, the P-T-t path of the northern Sulu UHP belt is reconstructed. The data reflects two-stage exhumation of this terrane, including an early-stage (5.8 km/m.y.) and a later-stage slower (3.1 km/m.y.) exhumation processes. The faster exhumation during early decompression was probably enhanced by extensive melting activity recorded by the CL-dark zircon mantles from the orthogneisses.
期刊：
MINI-REVIEWS IN MEDICINAL CHEMISTRY,2024年 ISSN：1389-5575
作者机构：
[Ai, Qidi; Chen, Haodong; Feng, Juling; Yang, Yantao; Chen, Naihong; Liu, Yangbo] Hunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China;[Feng, Juling; Zhao, Lei] Research lab of translational medicine, Hengyang Medical College, University of South China, Hengyang, Hunan Province 421001, China;[He, Wenbin] Shanxi Key Laboratory of Chinese Medicine Encephalopathy, Shanxi University of Chinese Medicine, Taiyuan, 030024, China;[Chen, Naihong; Chu, Shifeng] State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
摘要：
Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through direct or indirect regulation of iron accumulation or lipid peroxidation. More and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that ferroptosis might be employed as a novel target of ginsenoside for disease therapy. This article examines the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in influencing disorders via ferroptosis.
作者：
Fujita, Mitsutoshi;He, Song;Sun, Yuan;Zhang, Jun
期刊：
Journal of High Energy Physics,2024年(1) ISSN：1029-8479
通讯作者：
Fujita, M
作者机构：
[Fujita, M; Fujita, Mitsutoshi] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[He, Song] Jilin Univ, Coll Phys, Ctr Theoret Phys, Changchun 130012, Peoples R China.;[He, Song] Albert Einstein Inst, Max Planck Inst Grav Phys, Muhlenberg 1, D-14476 Golm, Germany.;[Sun, Yuan] Cent South Univ, Sch Phys & Elect, Changsha 418003, Peoples R China.;[Zhang, Jun] Univ Alabama, Dept Phys & Astron, 514 Univ Blvd, Tuscaloosa, AL 35487 USA.
通讯机构：
[Fujita, M ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
Gauge-Gravity Correspondence;Holography and Condensed Matter Physics (AdS/CMT);Confinement
摘要：
We compute holographic entanglement entropy (EE) and the renormalized EE in AdS solitons with gauge potential for various dimensions. The renormalized EE is a cutoff-independent universal component of EE. Via Kaluza-Klein compactification of S1 and considering the low-energy regime, we deduce the (d - 1)-dimensional renormalized EE from the odd-dimensional counterpart. This corresponds to the shrinking circle of AdS solitons, probed at large l. The minimal surface transitions from disk to cylinder dominance as l increases. The quantum phase transition occurs at a critical subregion size, with renormalized EE showing non-monotonic behavior around this size. Across dimensions, massive modes decouple at lower energy, while degrees of freedom with Wilson lines contribute at smaller energy scales.
摘要：
Electrosorption holds extraordinary promise for uranium (U(VI)) capture but is still limited by the finite accessible active sites of electrode materials, poor surface wettability and its intrinsic co-ion repulsion effect. Here we originally designed KOH-etched porous graphitic carbon nitride (g-C3N4) as active material, and multi-functional crosslinked xanthan gum-polyacrylic acid (XG-PAA) as binder to fabricate g-C3N4-X electrode for U(VI) capture. The abundant in-plane nanopores on 2D g-C3N4 lamellar, rich O- and N-containing active sites, and 3D tough interconnected conductive architecture, endowed g-C3N4-X electrode with fast electron/ion transport channels, alleviated co-ions exclusion, superior electrochemical properties, and hydrophilicity. These unique structure characteristics enabled U(VI) ions to form micro electric-field attraction with negatively charged COO- groups in advance to alleviate co-ion repulsion, then to electro-migrate towards and coordinate with active sites, and eventually to be electrocatalytic reduced into U(IV) deposits. Consequently, the g-C3N4-X electrode exhibited a 1.87 times faster adsorption kinetics, a much higher removal ratio of 98.1% within 70 min than traditional PVDF-bound electrode. Meanwhile, the cumulative adsorption capacity of g-C3N4-X electrode after six cycles was up to 1459.1 mg g−1. This efficient, scalable, and cost-effective g-C3N4-X electrode represents a significant step forward toward the practical applications of U(VI) electrosorption.
期刊：
AMERICAN JOURNAL OF PATHOLOGY,2024年 ISSN：0002-9440
通讯作者：
Jiang, Yongliang;Wu, Xu
作者机构：
# The two authors contributed equally to this study and share co-first authorship.;Department of Pediatrics, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China;[Yongliang Jiang] Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China;[Qing Luo; Li Xie; Yunzhu Xi; Rong Li; Li Li; Feifan Li; Meiyun Zhao] The Second Affiliated Hospital, Pulmonary and Critical Care Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China;[Weixia Xuan] Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, China
通讯机构：
[Yongliang Jiang; Xu Wu] H;Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China<&wdkj&>Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China The Second Affiliated Hospital, Pulmonary and Critical Care Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
摘要：
Neutrophil extracellular traps (NETs) and pyroptosis are critical events in lung injury. This study investigated whether ficolin-A influences NET formation through pyroptosis to exacerbate lipopolysaccharide (LPS)-induced lung injury. The expression of ficolin-A/2, NETs, and pyroptosis-related molecules was investigated in animal and cell models. Knockout and knockdown (recombinant protein) methods were used to elucidate regulatory mechanisms. The Pearson correlation coefficient was used to analyze the correlation between ficolins and pyroptosis- and NET-related markers in clinical samples. In this study, ficolin-2 (similar to ficolin-A) showed significant overexpression in patients with acute respiratory distress syndrome. Invivo, knockout of ficolin-A, but not ficolin-B, attenuated lung inflammation and inhibited NET formation in the LPS-induced mouse model. DNase I further alleviated lung inflammation and NET formation in ficolin-A knockout mice. Invitro, neutrophils derived from Fcna(-/-)mice showed less pyroptosis and necroptosis than those from the control group after LPS stimulation. Additionally, gasdermin D knockdown or Nod-like receptor protein 3 inhibitor reduced NET formation. Addition of recombinant ficolin-2 protein to human peripheral blood neutrophils promoted NET formation and pyroptosis after LPS stimulation, whereas ficolin-2 knockdown had the opposite effect. Acute respiratory distress syndrome patients showed increased levels of pyroptosis- and NET-related markers, which were correlated positively with ficolin-2 levels. In conclusion, these results suggested that ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via gasdermin D-mediated pyroptosis.
摘要：
Metal halide perovskite (MHP) detectors are highly esteemed for their outstanding photoelectric properties and versatility in applications. However, they are unfortunately prone to degradation, which constitutes a significant barrier to their sustained performance. This review meticulously delves into the causes leading to their instability, predominantly attributable to factors such as humidity, temperature, and electric fields and, notably, to various radiation factors such as X-rays, gamma-rays, electron beams, and proton beams. Furthermore, it outlines recent advancements in strategies aimed at mitigating these detrimental effects, emphasizing breakthroughs in composition engineering, heterostructure construction, and encapsulation methodologies. At last, this review underscores the needs for future improvements in theoretical studies, material design, and standard testing protocols. In the pursuit of optimizing the chemical stability of MHP detectors, collaborative efforts are in an imperative need. In this way, broad industrial applications of MHP detectors could be achieved.
摘要：
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent years, increasing evidence highlights that CNPY2 has important functions in health and disease. Many new blood vessels need to be formed to meet the nutrient supply in the process of tumor growth. CNPY2 can participate in the development of tumors by promoting angiogenesis. CNPY2 also enhances neurite outgrowth in neurologic diseases and promotes cell proliferation and tissue repair, thereby improving cardiac function in cardiovascular diseases. Regrettably, there are few studies on CNPY2 in various diseases. At the same time, its biological function and molecular mechanism in the process and development of disease are still unclear. This paper reviews the recent studies on CNPY2 in cervical cancer, renal cell carcinoma, prostate cancer, colorectal cancer, lung cancer, gastric cancer, hepatocellular carcinoma, cerebral ischemia-reperfusion injury, spinal cord ischemia-reperfusion injury, Parkinson's disease, ischemic heart disease, myocardial ischemia-reperfusion injury, myocardial infarction, heart failure, and non-alcoholic fatty liver disease. The biological function and molecular mechanism of CNPY2 in these diseases have been summarized in this paper. Many drugs that play protective roles in tumors, cardiovascular diseases, non-alcoholic fatty liver disease, and neurologic diseases by targeting CNPY2, have also been summarized in this paper. In addition, the paper also details the biological functions and roles of canopy FGF signaling regulator 1 (CNPY1), canopy FGF signaling regulator 3 (CNPY3), canopy FGF signaling regulator 4 (CNPY4), and canopy FGF signaling regulator 5 (CNPY5). The mechanism and function of CNPY2 should be continued to study in order to accelerate disease prevention in the future.
作者机构：
[Hu, Linlin; Wei, Yanhong; Luo, Xiaoqiong; Liao, Meihua; Lu, Yiming; Wang, Junli] Reproductive Medicine, Guangxi Medical and Health Key Discipline Construction Project, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China;[Wei, Yanhong; Lei, Xiaocan] Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, China;[Lei, Xiaocan; Lu, Yiming; Wang, Junli] Industrial College of Biomedicine and Health Industry, Youjiang Medical University for Nationalities, Baise, 533000, China
摘要：
BACKGROUND: Due to changes in lifestyle and dietary habits, the global population with obesity is increasing gradually, resulting in a significant rise in the number of individuals having obesity. Obesity is caused by an imbalance between energy intake and consumption, leading to excessive fat accumulation, which interferes with normal human metabolism. It is also associated with cardiovascular disease, metabolic syndrome, male reproductive endocrine regulation disorders, systemic and local inflammatory reactions, excessive oxidative stress, and apoptosis. All these factors can damage the internal environment for sperm generation and maturation, resulting in male sexual dysfunction, a decline in sperm quality, and lower fertility. This study analyzes the trends and priorities of the effects of obesity on male reproductive disorders from a bibliometric perspective. METHODS: This study uses the Web of Science as the statistical source, covering all time spans. Tools like Web of Science, VOSviewer, and CiteSpace are used to analyze countries, institutions, authors, journals, and keywords in the field. Total publications, total citations, and average number of citations are selected for statistics. RESULTS: The results show that the research on the impact of obesity on male reproductive function can be roughly divided into three stages: the initial stage, the slow development stage, and the rapid development stage. Our statistical scope includes 463 highly relevant articles that we have screened. We found that the journal with the most publications in this field is Andrologia, and the institution with the highest total citations is the University of Utah. The most influential countries, institutions, and authors in this field are the United States, the University of Utah, and Carrell, Douglas. Currently, research related to the impact of obesity on male reproduction focuses mainly on three aspects: biochemistry, molecular biology, and reproductive biology. The keyword explosion results indicate that sperm, obesity, and male reproduction are at the forefront and trends of future research in this field. There has been a shift from basic biochemical and molecular research to research on molecular mechanisms relying on omics technologies. However, we have observed that the number of papers published in 2022 is lower than in 2021, indicating a growth interruption during this period. Considering that this deviation may be due to the impact of the COVID-19 pandemic, it may hinder the progress of certain experiments in 2022. In recent years, China has rapidly developed research in this field. However, the average citation rate is relatively low, indicating the need for Chinese scholars to improve the quality of their articles further. Based on our research and in the context of global obesity, men are at risk of increased infertility. Addressing this issue relies on our continued research into the mechanisms of obesity-related male reproductive disorders. Over the past forty-three years, with the contributions of scientists worldwide, research in this field has flourished. CONCLUSION: The impact of obesity on male reproductive disorders has been extensively studied. Currently, research in this field primarily focuses on male sperm function, sperm quality, and the effects or mechanisms of cells on male reproduction. Future trends in this field should concentrate on the relationship between male fertility and energy metabolism, as well as the endocrine function of adipose tissue. This study comprehensively analyzes the current research status and global trends in obesity and male reproductive disorders. We also discuss the future developments in this field, making it easier for researchers to understand its developmental history, current status, and trends, providing valuable reference for effective exploration in this area.
通讯机构：
[Peng, AG ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
(137)Cs;(239+240)Pu;Distribution characteristics;Lake East dongting;Lake sediments
摘要：
Plutonium-239+240 and (137)Cs in the environment can usually be used to track the impact of nuclear activities on the environment, and have become important tools in environmental geochemical studies. In this study, nine sediment cores (E1-E9) in Lake East Dongting were collected and measured for the activity concentration of (239+240)Pu, (137)Cs and the atomic ratio of (240)Pu/(239)Pu, and then their vertical distribution characteristics were analyzed. The results show that: the activity concentrations of (137)Cs and (239+240)Pu in Lake East Dongting ranged from 5.26±0.43 to 28.6±2.23 Bq kg(-1) and 0.29±0.02 to 1.37±0.09 Bq kg(-1), with an average of 7.48±0.68 Bq kg(-1) and 0.39±0.03 Bq kg(-1), respectively. The atomic ratios of (240)Pu/(239)Pu are 0.168±0.012-0.211±0.015, which are basically consistent with the global atmospheric deposition. The vertical profiles of (137)Cs and (239+240)Pu in sediment cores show obvious single-peak distribution in E1-E6 and bimodal distribution in E7-E9. The results of sedimentation rates calculated by (137)Cs and (239+240)Pu method ranged from 0.59cm y(-1) to 1.99cm y(-1) with a mean of 1.18cm y(-1) and 0.61cm y(-1) to 2.18cm y(-1) with a mean of 1.26cm y(-1). The inventories of (137)Cs and (239+240)Pu in nine sediment cores are 5.87-10.8 kBq m(-2) and 307-545 Bq m(-2), which are about 8-14 and 9-15 times the inventory in the global average atmospheric deposition at the same latitude respectively. Comparing the results of the sedimentation rates and the inventories from different sampling points indicates that extreme climatic events and human activities have a significant impact on sediment environment of Lake East Dongting.
摘要：
Uranium contamination is a key issue in the sustainable development of nuclear energy. In this study, a cellulose/sericite hybrid aerogel with a layer-stacked network structure (MCC/AS-P) was prepared for uranium-contaminated wastewater treatment. Systematic characterization and multiple-batch static adsorption experiments were conducted to analyze the aerogel's preparation, adsorption, and desorption. The kinetics demonstrated a noticeable transition between mass transfer diffusion control and mass transfer control, approaching adsorption equilibrium within 8 min and 180 min, respectively, wherein polymer layers led to a more stable adsorption process. Adsorption isotherm and thermodynamic studies established that the theoretical adsorption capacity of MCC/AS-P for U(VI) at T = 298 K could reach 374.5 mg.g(-1). The adsorption behavior was endothermic and spontaneous, and the DFT calculations demonstrated that the adsorption energy of MCC/AS for UO22+ was 506.5 kcal/mol. Temperature, U(VI) concentration, and desorption can all lead to a transition of the dominant mechanism between chemisorption and physisorption. After six swelling-deswelling adsorption cycles, the adsorption efficiency remained above 80%, and the structure remained intact. Furthermore, the excellent performance in terms of interference resistance and chemical stability offers potential for practical application.
摘要：
In order to improve the reliability and maintainability of rod control power cabinets in nuclear power plants, this paper uses insulated gate bipolar transistors (IGBTs), the key power device of rod control power cabinets, as the object of research on cross-working-condition fault prediction. An improved transfer learning (TL) model based on a temporal convolutional network (TCN) is proposed to solve the problem of low fault prediction accuracy across operating conditions. First, the peak emitter voltage of an IGBT aging dataset is selected as the source domain failure characteristic, and the TCN model is trained after the removal of outliers and noise reduction. Then, the time–frequency features are extracted according to the characteristics of the target domain data, and the target domain representation data are obtained using kernel principal component analysis (KPCA) for dimensionality reduction. Finally, the TCN model trained on the source domain is transferred; the model is fine-tuned according to the target domain data, and the learning rate, the number of hidden layer nodes, and the number of training times in the network model are optimized using the dung beetle optimization (DBO) algorithm to obtain the optimal network, making it more suitable for target sample fault prediction. The prediction results of this TCN model, the long short-term memory (LSTM) model, the gated recurrent unit (GRU) model, and the recursive neural network (RNN) model are compared and analyzed by selecting prediction performance evaluation indexes. The results show that the TCN model has a better predictive effect. Comparing the prediction results of the TCN-based optimized transfer learning model with those of the directly trained TCN model, the mean square error, root mean square error, and mean absolute error are reduced by a factor of two to three, which provides an effective solution for fault prediction across operating conditions.
摘要：
Curcumin (CUR) exhibits a definite curative effect in the treatment of depression. To identify potential antidepressant targets and mechanisms of action of CUR. This study used network pharmacology to explore the signaling pathways and CUR-related targets in depression. C57BL/6J mice (male,12-14weeks old) were randomly divided into four groups (n = 8): saline-treated (control mice), lipopolysaccharide (LPS, 2mg/kg/day, intraperitoneally), LPS + CUR (50mg/kg/day, intragastrically), and LPS + CUR + LY294002 (7.5mg/kg/day, intraperitoneally). After 1week, behavioral tests were performed. Then, neuronal damage in the prefrontal cortex of mice was evaluated by hematoxylin-eosin (HE) staining. We uncovered the main active mechanism of CUR against depression using Western blotting and enzyme-linked immunosorbent assay (ELISA). Gene set enrichment analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways showed that the most significantly enriched pathway in CUR against depression was the PI3K-Akt pathway. Moreover, 52 targets were significantly correlated with the PI3K-Akt signaling pathway and CUR-related targets. In addition, among the top 50 targets ranked by degree in the protein-protein interaction (PPI) network, there were 23 targets involved in the 52 intersection targets. Administration of LPS alone extended immobility time in the open field test (OFT) and tail suspension test (TST) and decreased sucrose consumption in the sucrose preference test (SPT). Pretreatment with CUR relieved LPS-induced changes in the behavioral tests, activity of the PI3K-Akt signaling pathway, neuronal damage in the prefrontal cortex (PFC), and inflammatory response. Moreover, inhibition of the PI3K-Akt signaling pathway by LY294002 blocked the therapeutic effects of CUR. Our study indicates that CUR may be an effective antidepressant agent in an LPS-induced mouse model, partly because of its anti-inflammatory action through the PI3K-Akt signaling pathway.
摘要：
An improved metallized polyethylene terephthalate (PET) substrate prepared by catechol (CA) and tetraethylenepentamine (TEPA) composites modification with electroless deposition (ELD) copper layer is presented. Through the polymerization of CA with TEPA, amino and imino groups were generated to adsorb the activated particles required for metallization. To achieve the practical application of this method, different catalytic approaches were validated. Under different catalytic conditions, the catalytic effect of UV light was most pronounced, reaching almost four times than that in darkness. The resulting solid copper layers exhibited highly reliable electrical properties, including a low resistivity of 2.73 mu omega cm, tightly spaced crystalline particles and excellent mechanical properties. The fabricated metallized PET substrates were verified for use in flexible circuit boards, demonstrating the compatibility of the proposed CA-TEPA composites modification method with the PET substrates. This method provides an effective approach to the metallization of the PET substrates, which has a widespread application in manufacturing of flexible electronics such as film capacitors.
期刊：
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY,2024年 ISSN：1574-8928
作者机构：
[Jiang, Baohong] Department of Pharmacy, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China;[Li, Na; Ye, Feng] State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China;[Du, Wei] The First People's Hospital of Changde, Xiangya School of Medicine, Central South University, Changde, China;[Zeng, Lijun; Zhu, Hongbo; Tang, Yuanbin; Luo, Lunqi] Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People's Republic of China
关键词：
Ganoderma lucidum spore powder;prognosis;propensity score matching;triple-negative breast cancer
摘要：
BACKGROUND: Ganoderma lucidum extracts are widely used as adjuvants in the treatment of triple-negative breast cancers (TNBC) in China. However, its clinical value in TNBC remains unclear. Therefore, we investigated the clinical effect of Ganoderma lucidum spore powder (GLSP) on prognosis in patients with early-stage TNBC in this study. METHODS: A total of 388 patients who were diagnosed with TNBC at the Sun Yat-sen University Cancer Center from February 2012 to December 2017 were retrospectively reviewed. The propensity score matching (PSM) method was applied to balance baseline data. Kaplan-Meier method and Cox proportional hazards model were used to evaluate the relationship between GLSP and prognosis. RESULTS: Of the 388 patients, 72 (18.6%) patients took GLSP. After PSM, 208 patients were selected for analysis, including 71 (34.1%) patients who took the powder. The median followup period was 51 months. The patients who took GLSP (the treatment group) and those who did not take GLSP (the control group) were similar in most clinico-pathological features before being matched. However, the proportion of patients who received breast-conserving surgery in the treatment group was higher (27.8% vs. 16.1%; p =0.021) than in the control group. No significant difference was found in the baseline data between the two groups for the matched cohort (all p >0.05). Univariate analysis and multivariate analysis showed that patients taking GLSP benefited from improved overall survival (OS) (HR=0.159, p = 0.002) and disease-free survival (DFS) (HR=0.232, p = 0.005) before being matched. The main result of the survival analysis after matching was similar to that described above. Patients in the treatment group achieved both greater OS and DFS benefits than patients in the control group (all p < 0.05). In stratified analysis according to TNM stages, after adjusting for the significant prognostic factors, multivariate analysis revealed that the treatment group had better OS than the control group for patients in stages II and III (HR=0.172, p =0.004). CONCLUSIONS: The results of this real-world propensity-score-matched study suggest that GLSP can improve OS and DFS in early-stage TNBC patients. A higher OS was observed for patients taking GLSP, particularly in stage II and stage III.
