PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway

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成果类型：

期刊论文

作者：

Tang, Shi-Lin;Chen, Wu-Jun;Yin, Kai;Zhao, Guo-Jun;Mo, Zhong-Cheng;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Zhao, Guo-Jun; Lv, Yun-Cheng; Jiang, Zhi-Sheng; Tang, Chao-Ke; Yu, Xiao-Hua; Yin, Kai; Ouyang, Xin-Ping; Chen, Wu-Jun; Mo, Zhong-Cheng; Tang, Shi-Lin; Kuang, Huai-Jun] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shi-Lin] Univ S China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[Chen, Wu-Jun] Univ S China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Kuang, Huai-Jun] Univ S China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Fu, Yu-Chang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.

通讯机构：

[Tang, Chao-Ke] U

Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;ABCG1;Atherosclerosis;IGF-1/PI3-K/Akt signaling pathway;LXRα;PAPP-A;SR-BI

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2012

卷：

222

期：

页码：

344-354

DOI：

10.1016/j.atherosclerosis.2012.03.005

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170278, 81101213, 81100211, 81070220]; Hunan Provincial Natural Sciences Foundation of China [10JJ9019]; Science and Technology Department of Heng Yang of Hunan Province [2010kj41]

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Pregnancy-associated plasma protein-A (PAPP-A) has been involved in the atherosclerotic process through regulation of local expression of IGF-1 that mediates the activation of the phosphatidylinositol-3 (PI3-K) and Akt kinase (Akt) signaling cascades which lead to constitutive nitric oxide formation, with its attending vasodilator, antiplatelet and insulin-sensitizing actions. In addition, IGF-1 may decreased cholesterol efflux through reductions of expression in ABCA1 and SR-B1 by the PI3-K/Akt signaling pathway. In the current study, we exami...

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PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway

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