Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells

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成果类型：

期刊论文

作者：

Liu, Mi-Hua*;Lin, Xiao-Long;Li, Jian;He, Jun;Tan, Tian-Ping;...

通讯作者：

Liu, Mi-Hua;Zhang, Yuan

作者机构：

[Wu, Shao-Jian; Liu, Mi-Hua; He, Jun; Chen, Yu-Dan; Fu, Hong-Yun; Chen, Li; Yu, Shan; Tan, Tian-Ping; Tian, Wei; Liu, Jun] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

[Lin, Xiao-Long] Guangzhou Med Univ, Peoples Hosp Huizhou 3, Dept Pathol, Huizhou 516002, Guangdong, Peoples R China.

[Li, Jian] BoAi Hosp Zhongshan, Dept Ultrason Diag, Zhongshan 528403, Guangdong, Peoples R China.

[Yuan, Cong] First Hosp Changsha, Dept Cardiol, Changsha 410005, Hunan, Peoples R China.

[Zhang, Yuan] Mawangdui Hosp, Dept Pathol, 89 Guhan Rd, Changsha 410016, Hunan, Peoples R China.

通讯机构：

[Liu, Mi-Hua] U

[Zhang, Yuan] M

Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

Mawangdui Hosp, Dept Pathol, 89 Guhan Rd, Changsha 410016, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Forkhead box O3a;High glucose;Oxidative stress;Resveratrol

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2016

卷：

期：

页码：

1689-1694

DOI：

10.3892/mmr.2015.4695

基金类别：

Graduate Student Research Innovation Project of Hunan province [CX2013B397]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Resveratrol is a polyphenolic compound found in wine, which is mainly produced by the grapevine and exerts chemopreventive effects against hepatocellular carcinoma. However, the underlying molecular mechanisms have remained to be fully elucidated. The present study assessed whether resveratrol-induced apoptosis was mediated via the activation of the forkhead box O3a (FoxO3a) transcription factor. It was demonstrated that resveratrol treatment induced apoptosis in HepG2 cells, and that this pro-apoptotic effect was accompanied with increases in the expression of apoptotic protein Bim. Following...

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Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells

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