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Pregnancy-associated plasma protein-A in atherosclerosis: Molecular marker, mechanistic insight, and therapeutic target

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成果类型:
期刊论文
作者:
Yu, Xiao-Hua;He, Lin-Hao;Gao, Jia-Hui;Zhang, Da-Wei;Zheng, Xi-Long;...
通讯作者:
Tang, Chao-Ke
作者机构:
[Tang, Chao-Ke; Yu, Xiao-Hua; He, Lin-Hao; Gao, Jia-Hui] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Med Res Expt Ctr,Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.
[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Cumming Sch Med,Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
通讯机构:
[Tang, Chao-Ke] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Med Res Expt Ctr,Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;CAD;IGF;IGFBP-4;PAPP-A
期刊:
Atherosclerosis
ISSN:
0021-9150
年:
2018
卷:
278
页码:
250-258
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Pregnancy-associated plasma protein-A (PAPP-A), a member of the metzincin metalloproteinase superfamily, can enhance local insulin-like growth factor (IGF) bioavailability through proteolytic cleavage of three IGF binding proteins. In patients with coronary atherosclerosis disease (CAD), elevated PAPP-A levels are significantly associated with a higher risk of cardiovascular events. Accumulating evidence indicates that this protease exerts a proatherogenic effect by altering a variety of pathological processes involved in atherosclerosis, including lipid accumulation, vascular inflammation, en...

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