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Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma

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成果类型:
期刊论文
作者:
Liu, Y. F.;Xiao, Z. Q.;Li, M. X.;Li, M. Y.;Zhang, P. F.;...
通讯作者:
Chen, Z-C
作者机构:
[Li, C.; Zhang, P. F.; Yi, H.; Xiao, Z. Q.; Li, F.; Liu, Y. F.; Yao, H. X.; Chen, Z-C; Li, M. X.; Li, M. Y.] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Proteom, Changsha 410008, Hunan, Peoples R China.
[Li, F.; Liu, Y. F.; Yao, H. X.; Chen, Z-C; Li, M. X.] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.
[Li, M. X.] Univ S China, Dept Histol & Embryol, Hengyang, Peoples R China.
[Chen, Y. H.] Univ So Calif, Los Angeles, CA USA.
[Chen, Z-C] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Proteom, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.
通讯机构:
[Chen, Z-C] C
Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Proteom, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.
语种:
英文
关键词:
Laser capture microdissection;Lung adenocarcinoma;Lymph node metastasis;Protein markers;Two-dimensional difference gel electrophoresis
期刊:
Journal of Pathology
ISSN:
0022-3417
年:
2009
卷:
217
期:
1
页码:
54-64
基金类别:
National Key Basic Research Programme of China [2001CB510207]; Ministry of Education of China [2002-48]; Science and Technology Committee of Hunan, China [04XK1001-1, 05SK1004-1]; Public Health Bureau of Hunan Province, China [Z02-04]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Metastasis is a common phenomenon and the major lethal cause of lung adenocarcinoma (AdC). To discover novel potential biomarkers associated with lymph node metastasis and prognosis in lung AdC, we assessed differences in protein expression between primary lung AdC with (LNM AdC) and without lymph node metastasis (non-LNM AdC) using a quantitative proteomic approach. Laser capture microdissection was performed to purify the cancer cells from primary lung AdC tissues. The differential proteins between the pooled microdissected non-LNM AdC and LN...

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