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Hydrogen Sulfide and Cellular Redox Homeostasis

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成果类型:
期刊论文
作者:
Xie, Zhi-Zhong;Liu, Yang;Bian, Jin-Song
通讯作者:
Xie, Z.-Z.
作者机构:
[Xie, Zhi-Zhong; Liu, Yang] Institute of Pharmacy & Pharmacology, University of South China, Hengyang, Hunan 421001, China
[Xie, Zhi-Zhong; Liu, Yang] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan 421001, China
[Bian, Jin-Song] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
通讯机构:
[Xie, Zhi-Zhong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
[Xie, Zhi-Zhong] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.
[Bian, Jin-Song] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117597, Singapore.
Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China
语种:
英文
关键词:
Antioxidant effect - Cellular redox - Human disease - Natural antioxidants - Pathophysiology - Reactive oxygen species - Ros generations
期刊:
Oxidative Medicine and Cellular Longevity
ISSN:
1942-0900
年:
2016
卷:
2016
页码:
6043038
基金类别:
Construct Program of the Key Discipline in Hunan Province; NUHS B2B Research Grant [NUHSRO/2011/012/STB/B2B-08]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Intracellular redox imbalance is mainly caused by overproduction of reactive oxygen species (ROS) or weakness of the natural antioxidant defense system. It is involved in the pathophysiology of a wide array of human diseases. Hydrogen sulfide (H2S) is now recognized as the third "gasotransmitters" and proved to exert a wide range of physiological and cytoprotective functions in the biological systems. Among these functions, the role of H2S in oxidative stress has been one of the main focuses over years. However, the underlying mechanisms for the antioxidant effect of H2S are still poorly comprehended. This review presents an overview of the current understanding of H2S specially focusing on the new understanding and mechanisms of the antioxidant effects of H2S based on recent reports. Both inhibition of ROS generation and stimulation of antioxidants are discussed. H2S-induced S-sulfhydration of key proteins (e.g., p66Shc and Keap1) is also one of the focuses of this review.

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