Studies on the Protective Effect of Silybin Against Low-Dose Radiation-Induced Damage to the Immune System

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Yu;Yu, Yanan;Gao, Yue;Ma, Lanfang;Xu, Jie;...

通讯作者：

Guan, H

作者机构：

[Ding, Lehan; Guan, Hua; Gao, Yue; Zhang, Yu; Yu, Yanan] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Ding, Lehan; Hu, Weixiang; Xu, Jie; Guan, Hua; Zhao, Hongling; Gao, Yue; Zhang, Yu; Yu, Yanan; Ma, Lanfang; Zhou, Ping-Kun] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Guan, Hua; Ma, Lanfang] Hebei Univ, Sch Life Sci, Baoding 071000, Peoples R China.

[Hou, Kai] Sichuan Agr Univ, Coll Agron, Chengdu 611130, Peoples R China.

通讯机构：

[Guan, H ] U

Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Hebei Univ, Sch Life Sci, Baoding 071000, Peoples R China.

语种：

英文

关键词：

immune damage;low-dose radiation;protection;silybin

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2025

卷：

期：

DOI：

10.3390/ijms26125656

基金类别：

National Natural Science Foundation of China; [32171238]; [82173466]; [82473579]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

With growing public concern about the health effects of low-dose radiation, numerous studies have demonstrated that low-dose radiation can cause damage to the immune system, making intervention measures essential. This study investigated the protective effects of silybin against low-dose radiation-induced immune system damage and its underlying mechanisms at both the cellular and animal levels. At the cellular level, CCK-8 assays, ROS measurements, and RT-qPCR analysis revealed that silybin alleviated the reduction in RAW264.7 cell proliferation, intracellular ROS levels, and inflammatory cyto...

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