期刊论文

Fang, Jiasheng

英文

PLOS ONE

1932-6203

2012

7

10

e46367-

10.1371/journal.pone.0046367

program of the national natural science foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000972, 81101643, 81171934, 81172189]; 863 national programNational High Technology Research and Development Program of China [2012AA02A206]; program of Introducing Talents of Discipline to UniversitiesMinistry of Education, China - 111 Project [111-2-12]; fund of Hunan Key Laboratory of Non-resolving Inflammation and Cancer; foundation for the author of excellent doctoral dissertation of Hunan ProvinceFoundation for the Author of National Excellent Doctoral Dissertation of China [741000001]; Program for Shenghua Yuying top talents of Central South University [7601110185]; Hunan Province Natural Sciences Foundation of ChinaNatural Science Foundation of Hunan Province [10JJ7003]; Fok Ying Tong Education FoundationFok Ying Tung Education Foundation [121036]

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Background MicroRNAs have been considered as a kind of potential novel biomarker for cancer detection due to their remarkable stability in the blood and the characteristics of their expression profile in many diseases. Methods We performed microarray-based serum miRNA profiling on the serum of twenty nasopharyngeal carcinoma patients at diagnosis along with 20 non-cancerous individuals as controls. This was followed by a real-time quantitative Polymerase Chain Reaction (RT-qPCR) in a separate cohort of thirty patients with nasopharyngeal carcinoma and thirty age- matched non-cancerous voluntee...