miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma

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成果类型：

期刊论文

作者：

Deng, Min;Tang, Hailin;Zhou, Yanhong;Zhou, Ming;Xiong, Wei;...

通讯作者：

Ma, Jian

作者机构：

[Ye, Qiurong; Li, Xiaoling; Ma, Jian; Zhou, Ming; Zheng, Ying; Guo, Xiaofang; Xiong, Wei; Zhou, Yanhong; Liao, Qianjin; Tang, Hailin; Deng, Min; Zeng, Xi; Li, Guiyuan] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.

[Liao, Qianjin; Tang, Hailin; Deng, Min; Zeng, Xi] Univ S China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Ma, Jian] Cent S Univ, Canc Res Inst, 110 Xiang Ya Rd, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Ma, Jian] C

Cent S Univ, Canc Res Inst, 110 Xiang Ya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

microRNA-216b;KRAS;Nasopharyngeal carcinoma

期刊：

JOURNAL OF CELL SCIENCE

ISSN：

0021-9533

年：

2011

卷：

124

期：

页码：

2997-3005

DOI：

10.1242/jcs.085050

基金类别：

China National Key Scientific Technology Programs [2006CB910502]; National 863 High Technology ProgramNational High Technology Research and Development Program of China [2007AA02Z170]; National Nature Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30871282]; Hunan Province Nature Scientific Foundation [08JJ3051]; 111 ProjectMinistry of Education, China - 111 Project [111-2-12]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

MicroRNAs (miRNAs) are small noncoding RNAs that are involved in various diseases, including cancer. In the present study, we found that miR-216b was downregulated in nasopharyngeal carcinoma (NPC) cell lines and specimens. Decreased expression of miR-216b was directly related to advanced clinical stage and lymph node metastasis. miR-216b levels correlated inversely with levels of KRAS protein during nasopharyngeal tumorigenesis. Furthermore, we demonstrated that miR-216b can bind to the 3′ untranslated region (UTR) of KRAS and inhibit express...

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miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma

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