MicroRNA Expression Abnormalities in Limited Cutaneous Scleroderma and Diffuse Cutaneous Scleroderma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhu, Honglin;Li, Yisha;Qu, Shunlin;Luo, Hui;Zhou, Yaou;...

通讯作者：

Zuo, Xiaoxia

作者机构：

[You, Yunhui; Wang, Yanping; Zhu, Honglin; Li, Yisha; Luo, Hui; Zhou, Yaou; Zhao, Hongjun; Zuo, Xiaoxia] Cent S Univ, Dept Rheumatol, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

[Xiao, Xianzhong] Cent S Univ, Dept Pathophysiol, Xiangya Sch Med, Changsha 410008, Hunan, Peoples R China.

[Qu, Shunlin] Univ S China, Dept Pathophysiol, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Zuo, Xiaoxia] Cent S Univ, Dept Rheumatol, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zuo, Xiaoxia] C

Cent S Univ, Dept Rheumatol, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Scleroderma;microarray;microRNA;target gene

期刊：

Journal of Clinical Immunology

ISSN：

0271-9142

年：

2012

卷：

期：

页码：

514-522

DOI：

10.1007/s10875-011-9647-y

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30671947, 30900588]; Graduate Research Innovation Fund of Hunan Province [CX2011B061]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Scleroderma (systemic sclerosis, SSc) is a complex autoimmune disease caused by progressive fibrotic replacement of normal tissue architecture, a progressive and ultimately fatal process that currently has no cure. Although dysregulation of microRNAs (miRNAs) is known to be involved in a variety of pathophysiologic processes, the role of miRNAs in SSc is unclear. In comparison with the normal skin tissues, miRNAs were aberrantly expressed in limited cutaneous scleroderma and diffuse cutaneous scleroderma skin tissues. We also identified miRNAs ...

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MicroRNA Expression Abnormalities in Limited Cutaneous Scleroderma and Diffuse Cutaneous Scleroderma

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