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Foam cells in atherosclerosis

ESI高被引SCI-EMedline
WOS被引频次:160
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成果类型:
期刊论文
作者:
Yu, Xiao-Hua;Fu, Yu-Chang;Zhang, Da-Wei;Yin, Kai;Tang, Chao-Ke
通讯作者:
Yin, K
作者机构:
[Yin, Kai; Tang, Chao-Ke] Univ South China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
[Fu, Yu-Chang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
[Yu, Xiao-Hua; Tang, Chao-Ke] Univ South China, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada.
[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada.
通讯机构:
[Yin, K] Univ South China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Foam cells;Atherosclerosis;CD36;ACAT1;ABCA1;ABCG1
期刊:
Clinica chimica acta; international journal of clinical chemistry
ISSN:
0009-8981
年:
2013
卷:
424
期:
00
页码:
245-252
文献类别:
WOS:Review
所属学科:
ESI学科类别:临床医学;WOS学科类别:Medical Laboratory Technology
入藏号:
WOS:000325042600045;PMID:23782937
基金类别:
National Natural Sciences Foundation of China [81070220, 81170278]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]
机构署名:
本校为第一且通讯机构
院系归属:
国防科学技术学院
医学院
药学与生物科学学院
摘要:
Atherosclerosis is a chronic disease characterized by the deposition of excessive cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence and development of atherosclerosis. The generation of these cells is associated with imbalance of cholesterol influx, esterification and efflux. CD36 and scavenger receptor class A (SR-A) are mainly responsible for uptake of lipoprotein-derived cholesterol by macrophages. Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterification. ATP-binding cassette transporters A1 (ABCA1), ABCG1 and scavenger receptor BI (SR-BI) play crucial roles in macrophage cholesterol export When inflow and esterification of cholesterol increase and/or its outflow decrease, the macrophages are ultimately transformed into lipid-laden foam cells, the prototypical cells in the atherosclerotic plague. The aim of this review is to describe what is known about the mechanisms of cholesterol uptake, esterification and release in macrophages. An increased understanding of the process of macrophage foam cell formation will help to develop novel therapeutic interventions for atherosclerosis. (c) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
参考文献:
Baldan A, 2006, ARTERIOSCL THROM VAS, V26, P2301, DOI 10.1161/01.ATV.0000240051.22944.dc
Bochem AE, 2013, EUR HEART J, V34, P286, DOI 10.1093/eurheartj/ehs376
Boden WE, 2011, NEW ENGL J MED, V365, P2255, DOI 10.1056/NEJMoa1107579
Cheng Bei, 2010, Cardiovasc Pathol, V19, pe159, DOI 10.1016/j.carpath.2009.07.001
Chiurchitiu V, 2011, PEPTIDES, V32, P80, DOI 10.1016/j.peptides.2010.09.024

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