Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting calreticulin expression in H9c2 cells

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成果类型：

期刊论文

作者：

Liu, Mi-Hua*;Zhang, Yuan;Lin, Xiao-Long;He, Jun;Tan, Tian-Ping;...

通讯作者：

Liu, Mi-Hua

作者机构：

[Yu, Shan; Tan, Tian-Ping; Wu, Shao-Jian; Liu, Mi-Hua; He, Jun; Chen, Yu-Dan; Fu, Hong-Yun; Chen, Li] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuan] Mawangdui Hosp, Dept Pathol, Changsha 410016, Hunan, Peoples R China.

[Lin, Xiao-Long] Third Peoples Hosp Huizhou, Dept Pathol, Huizhou 516002, Guangdong, Peoples R China.

[Yuan, Cong] First Hosp Changsha, Dept Cardiol, Changsha 410005, Hunan, Peoples R China.

[Li, Jian] Boai Hosp Zhongshan, Dept Ultrason Diag, Zhongshan 528403, Guangdong, Peoples R China.

通讯机构：

[Liu, Mi-Hua] U

Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

hydrogen sulfide;extracellular signal-regulated kinase 1/2;calreticulin;apoptosis;cardiomyocytes

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2015

卷：

期：

页码：

5197-5202

DOI：

10.3892/mmr.2015.4020

基金类别：

Medical Scientific Research Funds of Guangdong province [A2014810]; Graduate Student Research Innovation Project of Hunan province [CX2013B397]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Doxorubicin (DOX) is a potent and currently available antitumor therapeutic agent; however, its clinical application is limited by the occurrence of cardiotoxicity. Preliminary evidence indicates that hydrogen sulfide (H2S) may exert protective effects against DOX cardiotoxicity. Therefore, the aim of the present study was to investigate whether calreticulin (CRT) is involved in the cardioprotection of H2S against DOX-induced cardiotoxicity. DOX was observed to markedly induce injuries, including cytotoxicity and apoptosis, and also enhance the expression level of CRT. Notably, pretreatment of...

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Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting calreticulin expression in H9c2 cells

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