Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yin, Qing-hua;Yan, Feng-xiang;Zu, Xu-Yu;Wu, You-hua;Wu, Xiao-ping;...

通讯作者：

Zhuang, Ying-zhi

作者机构：

[Wu, Xiao-ping; Deng, Shu-wen; Wu, You-hua; Yin, Qing-hua; Liao, Ming-chu; Yin, Lei-lan; Zhuang, Ying-zhi] Univ S China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Peoples R China.

[Yan, Feng-xiang] Univ S China, Inst Pharm, Hengyang 421001, Peoples R China.

[Yan, Feng-xiang] Univ S China, Inst Pharmacol, Hengyang 421001, Peoples R China.

[Zu, Xu-Yu] Univ S China, Affiliated Hosp 1, Inst Clin Res, Hengyang 421001, Peoples R China.

通讯机构：

[Zhuang, Ying-zhi] U

Univ S China, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Carvacrol;Hepatocellular carcinoma;Apoptosis;Mitochondrial pathway;Mitogen-activated protein kinase pathway

期刊：

Cytotechnology

ISSN：

0920-9069

年：

2012

卷：

期：

页码：

43-51

DOI：

10.1007/s10616-011-9389-y

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Carvacrol is one of the members of monoterpene phenol and is present in the volatile oils of Thymus vulgaris, Carum copticum, origanum and oregano. It is a safe food additive commonly used in our daily life, and few studies have indicated that carvacrol has anti-hepatocarcinogenic activities. The rationale of the study was to examine whether carvacrol affects apoptosis of human hepatoma HepG2 cells. In this study, we showed that carvacrol inhibited HepG2 cell growth by inducing apoptosis as evidenced by Hoechst 33258 stain and Flow cytometric (...

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Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2

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