Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Nai-Li;Quan, Zi-Fang;Zhao, Tong;Yu, Xu-Dong;Xie, Qiang;...

通讯作者：

Wu, Heng;Zhu, Jian-Hong

作者机构：

[Zhao, Tong; Xie, Qiang; Wei, Nai-Li; Ma, Fu-Kai; Zhu, Jian-Hong; Tang, Qi-Sheng; Zeng, Jun; Wang, Fan] Fudan Univ, Huashan Hosp, Inst Brain Sci, Dept Neurosurg,Shanghai Med Coll,State Key Lab Me, Shanghai 20040, Peoples R China.

[Wei, Nai-Li] Lanzhou Univ, Dept Neurosurg, Hosp 2, Lanzhou 730030, Gansu, Peoples R China.

[Quan, Zi-Fang; Wu, Heng] Univ South China, Dept Neurol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Quan, Zi-Fang; Yu, Xu-Dong] Univ South China, Inst Neurosci, Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Zhu, Jian-Hong] Fudan Univ, Dept Neurosurg, State Key Lab Med Neurobiol, Inst Brain Sci,Shanghai Med Coll,Huashan Hosp, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China.

通讯机构：

[Wu, Heng] U

[Zhu, Jian-Hong] F

Univ South China, Dept Neurol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Fudan Univ, Dept Neurosurg, State Key Lab Med Neurobiol, Inst Brain Sci,Shanghai Med Coll,Huashan Hosp, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China.

语种：

英文

关键词：

Nai-Li Wei;* Zi-Fang Quan;* Tong Zhao;* Xu-Dong Yu;4 Qiang Xie;1 Jun Zeng;1 Fu-Kai Ma;1 Fan Wang;1 Qi-Sheng Tang;1 Heng Wu;3 Jian-Hong Zhu1

期刊：

NEUROPSYCHIATRIC DISEASE AND TREATMENT

ISSN：

1178-2021

年：

2019

卷：

页码：

1211-1229

DOI：

10.2147/NDT.S204818

基金类别：

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2018YFA0107900, 31771491, 81641056, 2019CXJQ01]; National Nature Science FoundationNational Natural Science Foundation of China (NSFC); Shanghai Manipal Government; [lzujbky-2017-80]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Background: Stress-related obesity might be related to the suppression of the hypothalamic- pituitary- adrenocortical axis and dysregulation of the metabolic system. Chronic stress also induces the dysregulation of the reward system and increases the risk of food addiction, according to recent clinical findings. However, few studies have tested the effect of chronic stress on food addiction in animal models. Purpose: The objective of this study was to identify whether chronic stress promotes food addiction or not and explore the possible mechan...

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Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens

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