Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway

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成果类型：

期刊论文

作者：

Hu, Min;Zou, Wei;Wang, Chun-Yan;Chen, Xi*;Tan, Hui-Ying;...

通讯作者：

Tang, Xiao-Qing;Chen, Xi

作者机构：

[Tan, Hui-Ying; Hu, Min; Tang, Xiao-Qing; Zou, Wei; Zeng, Hai-Ying; Zhang, Ping] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Tan, Hui-Ying; Gu, Hong-Feng; Hu, Min; Tang, Xiao-Qing; Zeng, Hai-Ying] Univ South China, Inst Neurosci, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan] Univ South China, Coll Med, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Xi] Univ South China, Coll Med, Dept Anat, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Chen, Xi] U

Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Neurosci, Coll Med, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Coll Med, Dept Anat, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

Oxidative Medicine and Cellular Longevity

ISSN：

1942-0900

年：

2016

卷：

2016

页码：

2153745

DOI：

10.1155/2016/2153745

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371485]; Zhengxiang Scholar Program of University of South China [2014-004]; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway. We showed that NaHS (0.03 or 0.1 mmol/kg/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4-hydroxy-2-trans-nonenal (4-HNE), as well as increased level of gluta...

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Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway

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