AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Jun;Luo, Di-Xian;Huang, Chenfei;Shen, Yi;Bu, Yiwen;...

通讯作者：

Cao, Deliang

作者机构：

[Shen, Yi; Huang, Chenfei; Luo, Di-Xian; Ma, Jun; Bu, Yiwen; Gao, Zachary; Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA.

[Luo, Di-Xian] First Peoples Hosp Chenzhou, Inst Translat Med, Chenzhou 423000, Peoples R China.

[Markwell, Stephen] So Illinois Univ, Sch Med, Div Stat & Res Consulting, Springfield, IL 62794 USA.

[Gao, John] Mem Med Ctr, Dept Pathol, Springfield, IL 62702 USA.

[Cao, Zhe; Liao, Duan-Fang] Univ S China, Inst Pharm & Pharmacol, Coll Pharm & Life Sci, Hengyang 421001, Peoples R China.

通讯机构：

[Cao, Deliang] S

So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

语种：

英文

关键词：

aldo-keto reductase 1B10;breast cancer;disease-related survival;prognostic marker;serum marker

期刊：

International Journal of Cancer

ISSN：

0020-7136

年：

2012

卷：

131

期：

页码：

E862-E871

DOI：

10.1002/ijc.27618

基金类别：

PHS 2011-1 SBIR Topic 304 Competitive Range (USA) [N43CO-2011-00124]; Department of Defense Breast Cancer Research ProgramUnited States Department of Defense [BC083555]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170807]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Aldo-keto reductase 1B10 (AKR1B10) is a secretory protein that is upregulated with tumorigenic transformation of human mammary epithelial cells. This study demonstrated that AKR1B10 was overexpressed in 20 (71.4%) of 28 ductal carcinomas in situ, 184 (83.6%) of 220 infiltrating carcinomas and 28 (87.5%) of 32 recurrent tumors. AKR1B10 expression in breast cancer was correlated positively with tumor size (p = 0.0012) and lymph node metastasis (p = 0.0123) but inversely with disease-related survival (p = 0.0120). Univariate (p = 0.0077) and multi...

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AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker

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