The authors gratefully acknowledge the support of the National Natural Science Foundation of China (No. 21177052 ), the Science and Technology Program of Hunan Province in China (No. 2010SK3039 ) and the Construct Program of the Key Discipline (Public Health and Preventive Medicine) in Hunan Province.
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
We proposed a novel strategy which combines graphene oxide-based background reduction with RCDzyme-based enzyme strand recycling amplification for ultrahigh sensitive detection of uranyl. The RCDzyme is designed to contain a guanine (G)-rich sequence that replaces the partial sequence in an uranyl-specific DNAzyme. This multifunctional probe can act as the target recognition element, DNAzyme and the primer of signal amplification. The presence of UO22+ can induce the cleavage of the substrate strands in RCDzyme. Then, each released enzyme stran...