Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice

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成果类型：

期刊论文

作者：

Chen, Lili;Cheng, Wen;Shivshankar, Pooja;Lei, Lei;Zhang, Xiaoyun;...

通讯作者：

Zhong, Guangming

作者机构：

[Chen, Lili; Zhang, Xiaoyun; Cheng, Wen; Lei, Lei; Shivshankar, Pooja; Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.

[Yeh, I-Tien] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA.

[Wu, Yimou; Chen, Lili] Univ S China, Dept Pathogen Biol, Hengyang, Peoples R China.

[Cheng, Wen] Cent S Univ, Dept Immunol, Xiangya Med Sch, Changsha, Hunan, Peoples R China.

[Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.

通讯机构：

[Zhong, Guangming] U

Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.

语种：

英文

关键词：

CD28 Antigens;CD40 Ligand;Chlamydia Infections;Chlamydia muridarum;Urinary Tract Infections

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2009

卷：

期：

页码：

3080-3089

DOI：

10.1128/IAI.00611-08

基金类别：

U.S. National Institutes of Health

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Infection with Chlamydia muridarum in the mouse urogenital tract can induce both protective immunity and inflammatory pathologies, which has been used as a model for understanding the immune and pathogenic mechanisms of C. trachomatis infection. We compared the roles of CD28- and CD40 ligand (CD40L)-mediated costimulation in C. muridarum infection. Mice with CD28 or CD80/CD86 gene knockout (KO) displayed an infection course similar to that of wild-type mice during both primary and secondary infection, suggesting that CD28-mediated costimulation...

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Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice

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