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Effects of Salinomycin on Cancer Stem Cell in Human Lung Adenocarcinoma A549 Cells

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成果类型:
期刊论文、会议论文
作者:
Wang, Yi*
通讯作者:
Wang, Yi
作者机构:
[Wang, Yi] Univ S China, Affiliated Hosp 2, Dept Urol, Stem Cell Res & Clin Ctr, Hengyang, Peoples R China.
[Wang, Yi] 35 Jiefang Xi Rd, Hengyang City 421001, Hunan, Peoples R China.
通讯机构:
[Wang, Yi] 3
35 Jiefang Xi Rd, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
A549 cells;cancer stem cell;lung adenocarcinoma;Salinomycin;anticancer activities;sulforhodamine B;colony formation assay;cancer tumorospheres;ALDH;flow cytometry;RT-PCR;4-Oct;NANOG;SOX2;paclitaxel
期刊:
Medicinal Chemistry
ISSN:
1573-4064
年:
2011
卷:
7
期:
2
页码:
106-111
会议名称:
2011(肿瘤)干细胞与转化研究国际学术研讨会
会议论文集名称:
2011(肿瘤)干细胞与转化研究国际学术研讨会论文集
会议时间:
2011-4-16
会议地点:
重庆
会议主办单位:
西南大学
基金类别:
National Natural Science FundNational Natural Science Foundation of China (NSFC) [30,972,998]; Hunan Provincial Department of Education [09A079]
机构署名:
本校为第一机构
摘要:
Lung cancer is a leading cause of death in human. Cancer stem cells have been regarded as basis for failure of current therapeutic options. Salinomycin was shown to kill these cancer stem cells in some types of cancer such as breast cancer and leukemia. The in vitro anticancer activities of salinomycin have been validated against the lung cancer cell line A549 via sulforhodamine B and colony formation assay. Salinomycin has been demonstrated to significantly rupture the in vitro lung cancer tumorospheres from ALDH positive A549 lung cells using flow cytometry. Expression of stem cell markers O...

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