Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Zhongyu;Chen, Chaoqun;Chen, Ding;Wu, Yimou;Zhong, Youmin;...

通讯作者：

Zhong, G

作者机构：

[Li, Zhongyu; Chen, Ding; Zhong, Youmin; Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.

[Li, Zhongyu] Cent S Univ, Xiangya Med Sch, Dept Parasitol, Changsha 410083, Peoples R China.

[Li, Zhongyu; Wu, Yimou; Chen, Chaoqun] Univ S China, Dept Microbiol & Immunol, Hengyang, Hunan, Peoples R China.

[Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.

通讯机构：

[Zhong, G] U

Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.

语种：

英文

关键词：

Bacterial Proteins;Chlamydia trachomatis;Gene Expression Profiling;Gene Expression Regulation, Bacterial;membrane proteins

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2008

卷：

期：

页码：

2746-2757

DOI：

10.1128/IAI.00010-08

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Although the Chlamydia trachomatis genome is predicted to encode 50 inclusion membrane proteins, only 18 have been experimentally localized in the inclusion membrane of C. trachomatis-infected cells. Using fusion proteins and anti-fusion protein antibodies, we have systematically evaluated all 50 putative inclusion membrane proteins for their localization in the infected cells, distribution patterns, and effects on subsequent chlamydial infection when expressed ectopically, as well as their immunogenicity during chlamydial infection in humans. ...

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Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome

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