Treponema pallidum inhibits CD4+T-cell proliferation through METAP2: insights from Mendelian randomization analysis

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成果类型：

期刊论文

作者：

Liu, Zhaoping;Zhang, Xiaohong;Lin, Ting;Ding, Xuan;Yu, Han;...

通讯作者：

Wu, Yimou;Zhao, FJ

作者机构：

[Wu, Yimou; Zhao, Feijun; Liu, Zhaoping] Univ South China, Inst Microbiol & Infect Dis, Hunan Prov Clin Res Ctr Accurate Diag & Treatment, Affiliated Hosp 1,Hengyang Med Sch,Dept Clin Lab M, Hengyang, Hunan, Peoples R China.

[Wu, Yimou; Gao, Ke; Zhao, Feijun; Ding, Xuan; Yu, Han; Yao, Jiangchen; Zhang, Xiaohong] Univ South China, Hengyang Med Coll, MOE Key Lab of Rare Pediat Dis, Hengyang 421001, Peoples R China.

[Wu, Yimou; Gao, Ke; Zhao, Feijun; Ding, Xuan; Yu, Han; Yao, Jiangchen; Zhang, Xiaohong] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Wu, Yimou; Gao, Ke; Zhao, Feijun; Ding, Xuan; Yu, Han; Yao, Jiangchen; Zhang, Xiaohong] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.

[Zhao, Feijun] Changsha Cent Hosp, Dept Clin Lab Med, Changsha 410004, Peoples R China.

通讯机构：

[Zhao, FJ ; Wu, YM] U

Univ South China, Hengyang Med Coll, MOE Key Lab of Rare Pediat Dis, Hengyang 421001, Peoples R China.

Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hengyang 421001, Peoples R China.

Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.

Univ South China, Inst Microbiol & Infect Dis, Hunan Prov Clin Res Ctr Accurate Diag & Treatment, Affiliated Hosp 1,Hengyang Med Sch,Dept Clin Lab M, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Mendelian randomization;Treponema pallidum;METAP2;Cerebrospinal fluid metabolites;CD4+T-cells

期刊：

AMB EXPRESS

ISSN：

2191-0855

年：

2025

卷：

期：

页码：

1-16

DOI：

10.1186/s13568-025-01940-3

基金类别：

This work was supported by the National Natural Science Foundation of China (no. 81971980), Major Scientific and Technological Projects for collaborative prevention and control of birth defects in Hunan Province (no. 2019SK1010), Hunan Province Natural Science Foundation (no. 2023JJ30530 and 2024JJ5343), Health High-Level Talents Major Scientific Research Project of Hunan Provincial Health Commission (R2023004), Health Research Key Project of Hunan Provincial Health Commission (no. 20221064723), Research funding of the First Affiliated Hospital of University of South China (no. 20230005-1015) and Scientific Research and Innovation Project of Postgraduates in Hunan Province (no. CX20220974).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Neurosyphilis (NS) is a chronic central nervous system infection caused by Treponema pallidum. Owing to its diverse clinical manifestations and the limited sensitivity of current diagnostic methods, NS is difficult to diagnose. Understanding the molecular mechanisms of NS and identifying reliable biomarkers are essential for improving diagnostic and therapeutic strategies. This study employed Mendelian randomization (MR) analysis to explore the causal relationships among protein ratio quantitative trait loci (rQTLs), cerebrospinal fluid (CSF) m...

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Treponema pallidum inhibits CD4+T-cell proliferation through METAP2: insights from Mendelian randomization analysis

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