MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages

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成果类型：

期刊论文

作者：

Zhang, Min;Wu, Jian-Feng;Chen, Wu-Jun;Tang, Shi-Lin;Mo, Zhong-Cheng;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Wu, Jian-Feng; Liu, Xiang-Yu; He, Ping-Ping; Ouyang, Xin-Ping; Chen, Wu-Jun; Peng, Juan; Zhang, Min; Li, Yuan; Lv, Yun-Cheng; Tang, Chao-Ke; Wang, Jia-Lin; Tang, Yan-Yan; Chen, Kong; Yao, Feng] Univ South China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Wu, Jian-Feng; Tian, Guo-Ping] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shi-Lin] Univ South China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[Wu, Jian-Feng; Tian, Guo-Ping] Univ South China, Dept Histol & Embryol, Hengyang 421001, Peoples R China.

[Tang, Deng-Pei] Univ Saskatchewan, Dept Biochem, Saskatoon, SK S7H 5E5, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;ACAT1;Atherosclerosis;CD36;Cholesterol homeostasis;LPL;apoA1;miR-27a/b

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2014

卷：

234

期：

页码：

54-64

DOI：

10.1016/j.atherosclerosis.2014.02.008

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170278, 81370377, 81270269, 81100211, 81300224]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China [2008-244]; construct program of the key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Rationale: Macrophage cholesterol homeostasis maintenance is the result of a balance between influx, endogenous synthesis, esterification/hydrolysis and efflux. Excessive accumulation of cholesterol leads to foam cell formation, which is the major pathology of atherosclerosis. Previous studies have shown that miR-27 (miR-27a and miR-27b) may play a key role in the progression of atherosclerosis. Objective: We set out to investigate the molecular mechanisms of miR-27a/b in intracellular cholesterol homeostasis. Methods and results: In the present study, our results have shown that the miR-27 fa...

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MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages

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