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γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway

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成果类型:
期刊论文
作者:
Tu, Wen-Zhi;Li, Bing;Huang, Bo;Wang, Yu;Liu, Xiao-Dan;...
通讯作者:
Rang, Wei-Qing
作者机构:
[Rang, Wei-Qing; Huang, Bo; Tu, Wen-Zhi; Tang, Yan; Zhou, Ping-Kun] Univ South China, Coll Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang 421000, Hunan, Peoples R China.
[Wang, Yu; Guan, Hua; Zhang, Shi-Meng; Tu, Wen-Zhi; Liu, Xiao-Dan; Zhou, Ping-Kun; Li, Bing] Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China.
[Rang, Wei-Qing] Univ South China, Coll Publ Hlth, Inst Environm Med & Radiat Hyg, 28 Changsheng West Rd, Hengyang 421000, Hunan, Peoples R China.
通讯机构:
[Rang, Wei-Qing] U
Univ South China, Coll Publ Hlth, Inst Environm Med & Radiat Hyg, 28 Changsheng West Rd, Hengyang 421000, Hunan, Peoples R China.
语种:
英文
关键词:
γH2AX;CHK2;DNA-PKcs;DNA damage;Mitosis
期刊:
FEBS Letters
ISSN:
0014-5793
年:
2013
卷:
587
期:
21
页码:
3437-3443
基金类别:
National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2012AA063501]; Chinese National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81071678, 81272994]; Lotus Scholars Program of Hunan Provincial People's Government
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Phosphorylated H2AX is considered to be a biomarker for DNA double-strand breaks (DSB), but recent evidence suggests that γH2AX does not always indicate the presence of DSB. Here we demonstrate the bimodal dynamic of H2AX phosphorylation induced by ionizing radiation, with the second peak appearing when G2/M arrest is induced. An increased level of γH2AX occurred in mitotic cells, and this increase was attenuated by DNA-PKcs inactivation or Chk2 depletion, but not by ATM inhibition. The phosphorylation-mimic CHK2-T68D abrogated the attenuatio...

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