Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Chi;Feng, Yansheng;Qu, Shunlin;Wei, Xing;Zhu, Honglin;...

通讯作者：

Xiao, Xianzhong

作者机构：

[Wei, Xing; Xiao, Xianzhong; Feng, Yansheng; Luo, Qi; Chen, Guangwen; Zhang, Chi; Zhu, Honglin; Liu, Meidong; Qu, Shunlin] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410078, Hunan, Peoples R China.

[Wei, Xing; Zhang, Chi; Qu, Shunlin] Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Xianzhong] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Xiao, Xianzhong] C

Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

Resveratrol;Doxorubicin;SIRT1;p53;Apoptosis

期刊：

Cardiovascular Research

ISSN：

0008-6363

年：

2011

卷：

期：

页码：

538-545

DOI：

10.1093/cvr/cvr022

基金类别：

This work was supported by grants from the Major National Basic Research Program of China (no. 2007CB512007).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Aims Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of clinical antineoplastic activity, but increased apoptosis has been implicated in its cardiotoxicity. Resveratrol (RES) was shown to harbour major health benefits in diseases associated with oxidative stress. In this study, we aimed to determine the effect of RES on DOX-induced myocardial apoptosis in mice. Methods and results Male Balb/c mice were randomized to one of the following four treatments: saline, RES, DOX, or RES plus DOX (10 mice in each group). DOX treatment mar...

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Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

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