Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Su, Bo;Su, Jian;Zeng, Ying;Liu, Fang;Xia, Hong;...

通讯作者：

Jiang, Hao;Su, Qi

作者机构：

[Jiang, H; Su, Q; Zhang, Shuo; Su, Bo; Su, Qi; Zhou, Zhi-Gang; Ling, Hui; Jiang, Hao; Ai, Xiao-Hong; Su, Jian; Yang, Bang-Min; Zeng, Ying; Wu, You-Hua; Xia, Hong; Zeng, Xi; Liu, Fang; Ma, Yan-Hua] Univ South China, Affiliated Hosp 1, Ctr Gastr Canc Res Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Shuo; Su, Bo; Su, Qi; Zhou, Zhi-Gang; Ling, Hui; Su, Jian; Yang, Bang-Min; Zeng, Ying; Xia, Hong; Zeng, Xi; Liu, Fang; Ma, Yan-Hua] Univ South China, Key Lab Canc Cellular & Mol Pathol Hunan Prov Uni, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Su, Bo] Univ South China, Inst Pharm & Pharmacol, Key Lab Pharmacoprote Hunan Prov Univ, Hengyang 421001, Hunan, Peoples R China.

[Su, Jian] Univ South China, Affiliated Hosp 2, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Jiang, H; Su, Q; Su, Qi] U

Univ South China, Affiliated Hosp 1, Ctr Gastr Canc Res Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Key Lab Canc Cellular & Mol Pathol Hunan Prov Uni, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

LIMK1;diallyl disulfide;gastric cancer cell epithelial-mesenchymal transition;invasion;proliferation

期刊：

Oncotarget

ISSN：

1949-2553

年：

2016

卷：

期：

页码：

10498-10512

DOI：

10.18632/oncotarget.7252

基金类别：

National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30600285, 31000629, 31100935, 81102854]; Key Project Foundation of the Science and Technology program of Hunan Province of China [04SK1004]; Key Project of Scientific Research Foundation of Hunan Province Education Department of China [09A077]; Key Hunan Provincial Natural Science Foundation of China [07JJ3033]; Construct Program of the Key Discipline in Hunan Province of China [2011-76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Diallyl disulfide (DADS) has been shown to have multi-targeted antitumor activities. We have previously discovered that it has a repressive effect on LIM kinase-1 (LIMK1) expression in gastric cancer MGC803 cells. This suggests that DADS may inhibit epithelial-mesenchymal transition (EMT) by downregulating LIMK1, resulting in the inhibition of invasion and growth in gastric cancer. In this study, we reveal that LIMK1 expression is correlated with tumor differentiation, invasion depth, clinical stage, lymph node metastasis, and poor prognosis. DADS downregulated the Rac1-Pak1/Rock1-LIMK1 pathwa...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问