期刊论文

Li, Guo-Qing

英文

世界胃肠病学杂志：英文版

1007-9327

2009

15

44

5541-5548

10.3748/wjg.15.5541

Supported by Grant from Hunan Provincial Science and Technology Department （2008 FJ 3088）, China ACKNOWLEDGMENTS The authors thank Dr. Harry Hua Xiang Xia （Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA） for his critical review of the manuscript.

本校为第一且通讯机构

AIM: To investigate the effects of macrophage migration inhibitory factor (MIF) on proliferation of human gastric cancer MGC-803 cells and expression of cyclin D1 and p27~(Kip1) in them, and further determine whether the effects are related to the PI3K/Akt signal transduction pathway. METHODS: Gastric cancer MGC-803 cells were cultured and then treated with 50 μg/L recombinant human MIF (rhMIF) with and without a PI3K inhibitor, LY294002 (25 μmol/L). MTT assay was used to detect the proliferation of MGC-803 cells. Cell cycle was detected by f...