Autophagy regulates vascular endothelial cell eNOS and ET-1 expression induced by laminar shear stress in an ex vivo perfused system

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Guo, Fengxia;Li, Xiaohong;Peng, Juan;Tang, Yaling;Yang, Qin;...

通讯作者：

Wei, Dangheng

作者机构：

[Chen, Ruixing; Yang, Qin; Jiang, Zhisheng; Liu, Lushan; Peng, Juan; Wei, Dangheng; Li, Xiaohong; Guo, Fengxia; Tang, Yaling; Xiao, Ming; Wang, Zuo; Ni, Chuyu] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China.

[Wei, Dangheng; Wang, Gui-xue] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Bioengn Coll, Chongqing 400044, Peoples R China.

[Guo, Fengxia] Second People Hosp Heze City, Heze 274000, Shandong, Peoples R China.

通讯机构：

[Wei, Dangheng] U

Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Autophagy;Steady laminar shear stress;Endothelial cells;Endothelial nitric oxide synthase;Endothelin-1

期刊：

Annals of Biomedical Engineering

ISSN：

0090-6964

年：

2014

卷：

期：

页码：

1978-1988

DOI：

10.1007/s10439-014-1033-5

基金类别：

The present research is supported by the National Natural Science Foundation of China (81370378, 30800449), the construct program of the key discipline in Hunan province and key grant from the National Natural Science Foundation of China (No. 11332003).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Vascular endothelial cell function responds to steady laminar shear stress; however, the underlying mechanisms are not fully elucidated. In the present study, we examined the effect of steady laminar shear stress on vascular endothelial cell autophagy and endothelial cell nitric oxide synthase (eNOS) and endothelin-1 (ET-1) expression using an ex vivo perfusion system. Human vascular endothelial cells and common arteries of New Zealand rabbits were pretreated with or without rapamycin or 3-MA for 30 min. These were then placed in an ex vivo cel...

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Autophagy regulates vascular endothelial cell eNOS and ET-1 expression induced by laminar shear stress in an ex vivo perfused system

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