Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Guo-Jun;Tang, Shi-Lin;Lv, Yun-Cheng;Ouyang, Xin-Ping;He, Ping-Ping;...

通讯作者：

Yin, Kai

作者机构：

[Yin, Kai; He, Ping-Ping; Ouyang, Xin-Ping; Chen, Wu-Jun; Zhang, Min; Zhao, Guo-Jun; Lv, Yun-Cheng; Tang, Chao-Ke; Lu, Qian; Tang, Yan-Yan; Yao, Feng; Tang, Shi-Lin] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Zhao, Guo-Jun] Univ South China, Dept Histol & Embryol, Hengyang, Hunan, Peoples R China.

[He, Ping-Ping] Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.

[Fu, Yuchang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

通讯机构：

[Yin, Kai] U

Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Cholesterol;Transcription factors;Macrophages;Inflammation;Phosphorylation;Atherosclerosis;MicroRNAs;Inflammatory diseases

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2013

卷：

期：

页码：

e74782-

DOI：

10.1371/journal.pone.0074782

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81200218, 81070220, 81170278]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

ATP-binding cassette transporter A1 (ABCA1) is critical in exporting cholesterol from macrophages and plays a protective role in the development of atherosclerosis. The purpose of this study was to investigate the effects of betulinic acid (BA), a pentacyclic triterpenoid, on ABCA1 expression and cholesterol efflux, and to further determine the underlying mechanism. BA promoted ABCA1 expression and cholesterol efflux, decreased cellular cholesterol and cholesterol ester content in LPS-treated macrophages. Furthermore, we found that BA promoted ABCA1 expression via down-regulation of miR-33s. T...

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Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression

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