Hydrogen sulfide reduces kidney injury due to urinary-derived sepsis by inhibiting NF-κB expression, decreasing TNF-α levels and increasing IL-10 levels

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Xian;Xu, Wujun;Wang, Yi;Luo, Hongmei;Quan, Suqin;...

通讯作者：

Luo, Zhigang

作者机构：

[Xie, Huang; Xu, Wujun; Chen, Xian; Wang, Yi; Luo, Zhigang; Long, Xiangyang; Zhu, Neng; Zhou, Jing; Quan, Suqin; Liu, Jun; Wu, Lei; Yang, Ning; Zhang, Tao] Univ South China, Affiliated Hosp 2, Dept Urol, Hengyang 421001, Hunan, Peoples R China.

[Luo, Hongmei] Univ South China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Luo, Zhigang] Univ South China, Affiliated Hosp 2, Dept Urol, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Luo, Zhigang] U

Univ South China, Affiliated Hosp 2, Dept Urol, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

IL-10;NF-kappaB;TNF-alpha;hydrogen sulfide;kidney injury;urinary-derived sepsis

期刊：

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN：

1792-0981

年：

2014

卷：

期：

页码：

464-470

DOI：

10.3892/etm.2014.1781

基金类别：

Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [13JJ9009]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The present study aimed to investigate the effect of hydrogen sulfide (H2S) on kidney injury induced by urinary-derived sepsis. Rabbits were randomly divided into control, sham, sepsis, NaHS 2.8 mumol/kg and NaHS 8.4 mumol/kg groups, with six rabbits in each group. Upper urinary tract obstruction and acute infection was induced to establish the sepsis model. Blood was collected to carry out a white blood cell (WBC) count, and creatinine (Cr) and blood urea nitrogen (BUN) analysis. Morphological changes were observed by hematoxylin and eosin (H&E) staining and transmission electron microscopy. ...

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Hydrogen sulfide reduces kidney injury due to urinary-derived sepsis by inhibiting NF-κB expression, decreasing TNF-α levels and increasing IL-10 levels

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