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Humoral and cellular immune responses induced by DNA vaccine based on major outer membrane protein of chlamydia trachomatis

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成果类型:
期刊论文
作者:
李忠玉;吴移谋;余敏君;陈超群
作者机构:
[李忠玉; 吴移谋; 余敏君; 陈超群] Department of Microbiology, School of Medicine, Nanhua University
语种:
中文
关键词:
沙眼衣原体;DNA疫苗;体液免疫应答;细胞免疫应答
关键词(英文):
Chlamydia trachomatis;DNA vaccine;Humoral immune response;Cellular immune response
期刊:
免疫学杂志
ISSN:
1000-8861
年:
2005
卷:
21
期:
6
页码:
457-459
基金类别:
ThisworkwassupportedbyHunanProvincialNaturalScienceFoundationofChina(04JJ3063)andHunanprovincialeducationdepartment(03C379);
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
目的构建沙眼衣原体主要外膜蛋白核酸疫苗,并观察其诱导小鼠产生的体液免疫和细胞免疫.方法将核酸疫苗(pcDNA3.1-MOMP)或对照空质粒(pcDNA3.1)注射于4~6周龄小鼠后腿股四头肌,每次剂量为100mg.间隔2周加强免疫2次.末次免疫后,ELISA法测定脾淋巴细胞培养上清液中IFN-γ及小鼠血清中抗MOMP水平;MTT法测定脾淋巴细胞特异性增殖反应.结果 小鼠接种核酸疫苗后,能产生特异性抗体,第3次免疫后抗体最高滴度达1:1024,培养上清液中IFN-γ达(532.0±45.4)pg/mL;实验组小鼠脾淋巴细胞刺激指数为3.94±0.25,其抗原特异性反应明显高于对照组.结论 沙眼衣原体主要外膜蛋白核酸疫苗能刺激机体产生特异的细胞免疫...
摘要(英文):
Objective To construct DNA vaccine containing MOMP gene of Chlamydia trachomatis and to observe immune response in mice. Methods Mice of 4 - 6 weeks old were immunized with pcDNA3.1-MOMP or pcDNA3.1 intramuscularly at a dose of 100 μg. Booster immunizations were employed at 2-week interval for two times. Specific antibody in the sera of mice and the level of IFN-γ in murine spleen lymphocyte supernatant were detected by ELISA. The proliferation response of spleen cells was detected by MTT assay. Results Significant specific antibody titers we...

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