Changes in microrna (mir) profile and effects of mir-320 in insulin-resistant 3t3-l1 adipocytes

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ling, Hong-Yan;Ou, He-Sheng;Feng, Shui-Dong;Zhang, Xiao-Ying;Tuo, Qin-Hui;...

通讯作者：

Liao, Duan-Fang

作者机构：

[Ling, Hong-Yan; Liao, Duan-Fang] Cent S Univ, Dept Pharmacol, Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China.

[Tang, Cao-Ke; Zhang, Liang; Yin, Wei-Dong; Liao, Duan-Fang] Univ S China, Res Ctr Life Sci, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Chen, Lin-Xi; Gao, Zhi-Ping; Zhang, Xiao-Ying; Zhu, Bing-Yang; Ou, He-Sheng; Ling, Hong-Yan; Tuo, Qin-Hui; Liao, Duan-Fang] Univ S China, Res Ctr Life Sci, Key Lab Pharmacoprote Hunan Prov, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Ling, Hong-Yan] Univ S China, Res Ctr Life Sci, Dept Physiol, Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Feng, Shui-Dong] Univ S China, Res Ctr Life Sci, Sch Publ Hlth, Dept Epidemiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liao, Duan-Fang] U

Univ S China, Res Ctr Life Sci, Key Lab Atherosclerol Hunan Prov, 28 W Chengsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

3T3-L1 adipocytes;Expression profile;Insulin resistance;MicroRNA;MiR-320;Phosphatidylinositol 3-kinase

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2009

卷：

期：

页码：

e32-e39

DOI：

10.1111/j.1440-1681.2009.05207.x

基金类别：

National Natural Science Foundation of China [30 770 868, 30 600 249]; National Major Basic Research Program of China [2006CB503808]; Natural Science Foundation of Hunan [07C0050]; Construct Program of the Key Discipline in Hunan Province; Constructing Program of Key Disciplines in Hunan Province; National Institutes of Health [AG21999]

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

公共卫生学院

摘要：

MicroRNAs (miRNAs) play essential roles in many biological processes. It is known that aberrant miRNA expression contributes to some pathological conditions. However, it is not known whether miRNAs play any role in the development of insulin resistance in adipocytes, a key pathophysiological link between obesity and diabetes. To investigate the function of miRNAs in the development of insulin resistance, using miRNA microarray analysis we compared miRNA expression profiles between normal insulin-sensitive 3T3-L1 adipocytes and 3T3-L1 adipocytes...

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Changes in microrna (mir) profile and effects of mir-320 in insulin-resistant 3t3-l1 adipocytes

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