National Natural Science Foundation of China
Major State Basic Research Development Program of China
National High Technology Research and Development Project of China
机构署名：
本校为其他机构
院系归属：
医学院
摘要：
In this study, a new poly(lactic acid)-poly (ethylene oxide)-Arg-Gly-Asp (PLA-PEO-RGD) derivative was synthesized, and paclitaxel-loaded PLA-PEO-RGD micelles were prepared by this derivative. The solubility assay showed that micelles mixed with Pluronic F-68 as surfactant could increase the solubility of this hydrophobic paclitaxel in aqueous solution. The cell-binding assay showed that PLA-PEO-RGD micelle (IC50 = 11.13 ±1.38 nmol/L) had about 3.6-fold higher integrin avidity than PLA-PEO-RGD conjugates (IC 50 = 40.33 ±3.12 nmol/L). The avidity of micelle was also higher than RGD...
