MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue

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期刊论文

作者：

Ling, H. -y.;Hu, B.;Hu, X. -b.;Zhong, J.;Feng, S. -d.;...

通讯作者：

Liao, D. -f.

作者机构：

[Ling, H. -y.; Hu, B.] Univ S China, Sch Med, Dept Physiol, Hengyang, Peoples R China.

[Liao, D. -f.] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Ling, H. -y.] Univ S China, Ctr Basic Med Postdoctoral Studies, Hengyang, Peoples R China.

[Hu, X. -b.] Univ S China, Sch Life Sci & Technol, Dept Biochem & Mol Biol, Hengyang, Peoples R China.

[Wen, G. -b.; Zhong, J.] Univ S China, Affiliated Hosp 1, Inst Clin Res, Hengyang, Peoples R China.

通讯机构：

[Liao, D. -f.] H

Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

miR-21;insulin resistance;PTEN;AKT

期刊：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

ISSN：

0947-7349

年：

2012

卷：

120

期：

页码：

553-559

DOI：

10.1055/s-0032-1311644

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000328, 81000946, 30971170]; Construct Program of the Key Discipline in Hunan Province; Constructing Program of Key Disciplines in Hunan Province; fifty-first batch of China Postdoctoral Sciences Foundation [2012M511384]

机构署名：

本校为第一机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

公共卫生学院

摘要：

Aims/hypothesis: Our previous study showed there was a change of microRNA (miRNA) expression profile, and miR-21 was significantly down regulated in insulin-resistant adipocytes (IR-adipocytes). Phosphatase and tensin homologs deleted on chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, was identified to be a target gene of miR-21, which suggested miR-21 might be associated with insulin resistance (IR) or diabetes. However, it is not known whether miR-21 play any role in the development of IR in...

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MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue

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